粘液表皮样癌间质反应的特点及生物学意义

CHARACTERISTICS OF MUCOEPIDERMOID-CARCINOMA MESENCHYMAL RESPONSE AND THEIR BIOLOGICAL SIGNIFICANCE

作者从形态学角度探讨粘液表皮样癌间质反应的特点及其生物学意义。发现:①癌间质中淋巴细胞、浆细胞、单核细胞浸润的量及网状纤维的量与癌的恶性度一致;②癌巢间及肿瘤过网状纤维反应在抗肿瘤过程中与机体的免疫反应起着相互协同、相互影响的作用;③间质中胶原纤维反应的类型可为机体对抗肿瘤的防御反应,或是促使瘤细胞向周围浸润、扩散;④间质中的胶原纤维,大部分可能由癌细胞产生,少部分可能由癌细胞产生的一种促生长因子使宿主纤维母细胞增生所致。

Characteristics of mucoepidermoid-carcinoma-mesenchymal response and their biological significance are discussed in this paper from the morphalogical point of view. Through this study we conclude: 1. The in- filtration amount of lymphatic cells, plasma cells, mononuclear cells and the reticular fiber amount are in accordance with the malignacy of carcinoma; 2. The reticular fiber response among cancer nests and around carcinoma during the process of anti-caueer embodies an inter-synergic and inter- effective function with the body's immunoreaction; 3. Different types of reactions of the collagenous fibers in the mesenchyme might be related to the anti-eahcer response of the organic body or to the factor that promotes the cancer cells to infiltrate and tospread to the surrounding parts; 4. As to the origin of the collagenous fibres in the mesenchyme, it is mostly caused by the cancer cells and partly by the somatomedin produced by the cancer cells, which can make the host fibroblast proliferate.