非洛地平对原发性高血压患者血浆一氧化氮、内皮素和降钙素基因相关肽含量的影响

THE EFFECT OF FELODIPINE ON PLASMA NITRIC OXIDE,ENDOTHELIN AND CALCITONIN GENE RELATED PEPTIDE IN PATIENTS WITH ESSENTIAL HYPERTENSION

目的:探讨原发性高血压(EH)患者血浆一氧化氮(NO)、内皮素(ET)和降钙素基因相关肽(CGRP)含量的变化及非洛地平对其影响。方法:观察124例EH患者(EH)组用非洛地平治疗前后血浆NO、ET和CGRP浓度的变化,并与30例正常人(对照组)进行对比分析。结果:非洛地平治疗前EH组血浆NO和CGRP明显低于对照组(P<0.01)。结论:非洛地平在有效降压的同时,能使EH患者血浆NO和CGRP浓度升高,ET浓度降低,对EH患者的血管内皮功能具有保护作用。

Objective：To observe the effect of felodipine on plasma nitric oxide（NO）,endothelin（ET） and calcitonin gene related peptide（CGRP） of essential hypertensive（EH） patients Method：The plasma NO,ET and CGRP,and the effect of felodipine intervention were observed in 124 EH;30 healthy subjects were included as control group.Results：The plasma NO and CGRP,levels in EH patients were significantly lower than those in notmal subjects（P0.01）;the plasma ET levels in EH patients were significantly higher than that in normal sub-jects（P0.01）,and after felodipine treatment,the blood pressure and the levels of plasma ET were significantly decreased and the levels of plasma NO and CGRP were significantly increased in EH patients（P0.01）.Conclu-sion：Besides decreasing blood pressure,felodipine can improve the levels of plasma NO、CGRP and decrease the levels of plasma ET in EH patients.Felodipine possesses a good protective effect on the vascular endothelial function of EH patients.