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Twist-肿瘤侵袭转移及耐药的新因子 被引量：3

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摘要 Twist是进化过程中的一个保守转录因子，可调节胚胎发育过程中的细胞重建，并赋予细胞迁移的能力。自从2004年Weinberg在小鼠乳腺癌肺转移模型中发现Twist基因的重要作用后，研究人员开始关注肿瘤事件中Twist的作用。新近研究显示．Twist在人类肿瘤的发生和转移中发挥了重要作用。其过度表达与癌症的侵蚀性和低存活率成正相关。此外，还发现Twsit在肿瘤细胞化疗药物抗性产生中发挥着重要作用。
作者 张永亮 何涛
机构地区 泸州医学院医学分子生物学实验室
出处 《泸州医学院学报》 2010年第4期462-464,共3页 Journal of Luzhou Medical College
关键词 肿瘤侵袭转移 转录因子 TWIST基因 耐药 胚胎发育过程 小鼠乳腺癌 细胞重建 细胞迁移
分类号 Q71 [生物学—分子生物学] R737.9 [医药卫生—肿瘤]
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参考文献20

  • 1Yang J,Mani SA,Donaher JL,et al.Twist,a master regulator of morphogenesis,plays an essential role in tumor metastasis[J].Cell,2004;117(7):927.
  • 2Puisieux A,Valsesia-Wittmann S,Ansieau S.A Twist for survival and cancer progression[J].Br J Cancer,2006;Jan 16;94(1):13.
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二级参考文献20

  • 1王其,陈孝平,张万广,张必翔.人肝癌HepG2多药耐药细胞系的部分生物学性状研究[J].中华实验外科杂志,2004,21(5):538-540. 被引量：40
  • 2Jing Yang,Sendurai A,Mani,Joana Liu Donaher,et al.Twist,a Master Regulkator of Morphogenesis,Plays an Essential Role in Tumor Metastasis[J].Cell,2004,117:927-939.
  • 3Castanon I,Baylies MK.A Twist in fate:evolutionary comparison of Twist structure and function[J].Gene,2002,287:11-22.
  • 4Hay ED.An overview of epithelio-mesenchymal transformation[J].Acta Anat.(Basel),1995.154:8-20.
  • 5Thiery JP.Epithelial-mesenchymal transitions in tumour progression[J].Nat Rev Cancer,2002,2:442-454.
  • 6Erika Rosivatz,Ingrid Becker,katija Specht,et al.Differential Expression of the Epit helial-Mesenchymal Transition Regulators Snail,SIP1,and Twist in Gastric Cancer[J].Am J Pathol,2002,161:1881-1891.
  • 7Zorzos HS,Lazaris AC,Korkolopoulour PA.Multidrug resistance proteins and topoisomerase Ⅱ alpha expression in colon cancer:association with metastatic potential[J].Pathology,2003,Aug,35(4):315-8
  • 8Kang Y,Massague J.Epithelial-mesenchymal transitions:Twist in development and metastasis[J].Cell,2004,118(3):277～279
  • 9Thiery JP.Epithelial-mesenchymal transitions in tumor progression[J].Nat Rev Cancer,2002,2(6):442～454
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共引文献21

同被引文献34

  • 1李曼,潘琳娜,张志燕,苏荣龄.b-FGF在食管癌中的表达及临床意义[J].实用肿瘤学杂志,2006,20(4):324-325. 被引量：3
  • 2Ansieau S,Bastid J,Doreau A,et al.Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence[J].Cancer Cell,2008,14(1):79-89.
  • 3Thisse B,Stoetzel C,Gorostiza-Thisse C,et al.Sequence of the Twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos[J].EMBO J,1988,7(7):2175-2183.
  • 4Cai J,Goodman BK,Patel AS,et al.In creased risk for developmental delay in Saethre-Chotzen syndrome is associated with Twist deletions:an improved strategy for Twist mutation screening[J].Hum Genet,2003,114(1):68-76.
  • 5Puisieux A,Valsesia-Wittmann S.Cancer cells escape from failsafe programs in a simple Twist[J].Bull Cancer,2006,93(3):251-256.
  • 6Maestro R,Dei Tos AP,Hamamori Y,et al.Twist is a potential oncogene that inhibits apoptosis[J].Genes Dev,1999,13(17):2207-2217.
  • 7Yang J,Mani SA,Weinberg RA.Exploring a new twist on tumor metastasis[J].Cancer Res,2006,66(9):4549-4552.
  • 8Hu L,Roth JM,Brooks P,et al.Twist is required for thrombin-induced tumor angiogenesis and growth[J].Cancer Res,2008,68(11):4296-4302.
  • 9Mironchik Y,Winnard PT Jr,Vesuna F,et al.Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer[J].Cancer Res,2005,65(23):10801-10809.
  • 10Niu RF,Zhang L,Xi GM,et al.Up-regulation of Twist induces angiogenesis and correlates with metastasis in hepatocellular carcinoma[J].J Exp Clin Cancer Res,2007,26(3):385-394.

引证文献3

二级引证文献4

泸州医学院学报
2010年 第4期

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