锁阳茎的化学成分及其药理活性研究

Studies on Chemical Constituents and Pharmacological Effects of the Stem of Cynomorium songaricum Rupr.

目的：为了开发锁阳药用资源，并为临床用药和质量控制提供科学依据。方法：利用化学和光谱方法对锁阳的化学成分进行了研究；采用小鼠甲基红排便实验和小鼠氢化考的松肾阳虚动物模型对锁阳不同提取部位进行了润肠通便和补肾阳的药理活性研究。结果和结论：从锁阳的肉质茎中分离得到１２个化合物，鉴定了其中７个化合物：β谷甾醇、棕榈酸、熊果酸、胡萝卜甙、（－）儿茶素、柑桔素４′Ｏ吡喃葡萄糖甙、琥珀酸，其中（－）儿茶素和琥珀酸为首次从锁阳中分离得到；药理结果表明锁阳各提取部位均有较明显的润肠通便和补肾阳作用。

Objective:In order to exploit the medicinal resources and provide a scientific evidence for the clinical use and quality of Cynomorium songaricum control, the chemical constituents and pharmacological effects of the stem of the plant were studied preliminarily.Method:The chemical constituents were studied by spectral analysis and chemical method.The pharmacological effects were studied by an experiment on the defecation and deficiency of kidney function.Result and Conclusion:Seven compounds were isolated from the stem of C.songaricum and identified as β sitosterol(I), palmitic acid (Ⅱ), ursloic acid (Ⅲ),daucosterol (Ⅳ),(-) catechin (Ⅵ),naringenin 4′ O pyranogluoside (Ⅶ) and succinicacid (Ⅻ). Compounds Ⅵ and Ⅻ were isolated from this species for the first time. The pharmacological results show that the different extracts facilitate catharsis and replenish the deficiency of kidndey yang.