桃蛭枳朴合剂预防术后肠粘连的临床研究

Clinical Study on Preventive Effect of Taozhi Zhipu Mixture on Postoperative Intestinal Adhesion

目的：观察桃蛭枳朴合剂预防腹部术后肠粘连的临床疗效。方法：３９６例腹部手术患者随机分为防粘组１８８例和对照组２０８例，防粘组予桃蛭枳朴合剂口服或胃管中注入；对照组不予本合剂，余处理相同。观察两组首次肠鸣音恢复时间，首次排气排便时间，及用同位素Ｉ１３１胶囊示踪观察胃肠蠕动，用肠音描记仪描记肠鸣音频率、强度，２～３年后进行疗效随访。结果：防粘组肠鸣音恢复时间、首次排气排便时间明显早于对照组，Ｉ１３１胶囊在肠道中下移迅速、肠音描记频率快、波幅大，远期随访亦发现防粘组无粘率及总体疗效明显优于对照组（Ｐ＜００５）。结论：桃蛭枳朴合剂具有明显的促进术后胃肠蠕动，预防粘连发生的作用。

Objective: To study the clinical effect of Taozhi Zhipu Mixture (TZM) in preventing postoperative intestinal adhesion. Methods: Three hundred and ninety six patients who had received abdominal operation were randomly divided into the treated group (188 cases) and the control group (208 cases). Same treatment was given to both groups excepting that the treated group received TZM orally or by nasogastric tube. The time of borborygmus recovering and first passing of flatus defecation after operation was recorded. Patient′s gastro intestinal motion was observed by isotope tracing with I 131 capsule. The frequency and intensity of borborygmus were measured by a tracer. All patients had been followed up for 2-3 years. Results: The recovery of borborygmus, the first passing of flatus defecation were much earlier, the I 131 capsule passed gastro intestinal tract more quickly, and tracer showed higher frequency and intensity of borborygmus in the treated group than those in the control group. Follow up study also showed the treated group was better than the control group in the non adhesion rate and the total effective rate (P<0 05). Conclusion: TZM has good effect on stimulating postoperational gastro intestinal peristalsis and preventing the occurrence of postoperational intestinal adhesion.