摘要
目的：探讨肾衰宁对系膜细胞增殖及其分泌细胞因子白细胞介素－１（ＩＬ１）的影响。方法：采用血清药理学方法，提取动物的含药血清作用于体外培养的人系膜细胞（ＨＭＣ）体系，观察具有益气固本、化瘀泻浊作用的中药肾衰宁对ＨＭＣ增殖及其分泌细胞因子ＩＬ１的影响。结果：肾衰宁具有抑制ＨＭＣ增殖及其分泌细胞因子ＩＬ１的作用，该抑制作用具有一定的量效关系。结论：ＨＭＣ是肾衰宁发挥治疗作用的重要靶细胞，这可能是该方防治慢性肾功能衰竭的机制之一。
Objective: To explore the effect of Shenshuaining (SSN), on the proliferation of human mesangial cells (HMC) and the autocrine secretion of interleukin 1 (IL 1). Methods: SSN, a preparation of Chinese herbal drug having actions of Qi supplementing, origin consolidation, blood stasis resolving and turbid substance removing, medicated serum of animal was extracted by pharmacologic method and its effect on proliferation and autocrine IL 1 secretion of HMC was observed. Results: SSN could inhibit the proliferation and IL 1 autocrine secretion of HMC, and the inhibition was dose dependent. Conclusion: Mesangial cell is the important target cell for action of SSN, the inhibition on HMC may be one of the mechanisms of SSN in prevention and treatment of chronic renal failure.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1999年第5期299-301,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
四川省中医管理局资助
关键词
肾衰宁
人系膜细胞
肾功能衰竭
IL-1
药理
Shenshuaining
human mesangial cell
interleukin 1
chronic renal failure
