解郁散对大鼠郁证模型行为学影响

Effect of Jieyu Pender on Behavioristics in Rat Model with Melancholia

目的:观察解郁散对郁症模型大鼠行为的影响。方法:40只SD雄性大鼠随机平均分为对照组、模型组、解郁散组和百忧解组。应用分养和长期不可预见的中等强度应激造成大鼠恶劣心境障碍模型。以Open-Field法和糖水消耗实验对照研究慢性应激诱导的恶劣心境障碍模型大鼠行为的改变。结果:与对照组比较,模型组大鼠Open-Field评分降低,糖水消耗量减少;与模型组比较,各治疗组大鼠在治疗后Open-Field评分升高,糖水消耗量增加。结论:解郁散可改变大鼠郁症模型的抑郁行为,提示解郁散具有一定的抗抑郁作用。

Objective：To investigate the effect of Jieyu powder on behavior in rat model with melancholia.Methods：All 40 male SD rats were randomly allocated to 4 groups as follows：control,model,and Jieyu powder Fluoxetine.The Dysthymic model of rat was produced by separation and chronic unpredictaboe mild stress.The behavior of rat was detected by Open-Field test.Open-Field and sucrose consumption were used to study the chandges of rat behavior.Results：The results showed that the Fluoxetine,jieyu decoction are increase after treatment.Conclusion：These data suggest that jieyu decoction was effective in the treatment of Dysthymia.