长柱十大功劳与阔叶十大功劳水提物药理作用比较

Long columns and broad-leaved Mahonia Mahonia Comparative pharmacological effects of aqueous extract

目的:观察并比较长柱十大功劳与阔叶十大功劳水提物的药理作用,为长柱十大功劳的开发利用提供依据。方法:采用小鼠耳廓肿胀法、醋酸扭体法、番泻叶致小鼠腹泻法、异硫氰酸萘酯所致肝损伤模型,并对长柱十大功劳水提物进行急性毒性试验。结果:两种十大功劳水提物都具有抗炎、镇痛、止泻、保肝利胆的作用,长柱十大功劳水提物止泻作用优于阔叶十大功劳水提物,其最大给药量为402.00 g.kg-1。结论:长柱十大功劳与阔叶十大功劳水提物药理作用相近,提示其药用价值有深入研究的必要。

Objective： To observe and compare the long columns leaved Mahonia Mahonia and the pharmacological effects of aqueous extract for the long column Mahonia provide the basis for the development and utilization.Methods： The mouse ear edema and acetic acid writhing,senna induced diarrhea law,naphthyl isothiocyanate ester induced liver injury model,and the long column of water extract of Mahonia of acute toxicity test.Results： The aqueous extract of Mahonia has anti-inflammatory,analgesic,antidiarrheal,protective and choleretic effect,long column of water extract of Mahonia better than the broad-leaved Mahonia antidiarrheal effect of water extract The maximum dose volume of 402.00 g.kg-1.Conclusion： The long columns and broad-leaved Mahonia Mahonia similar pharmacological effects of aqueous extract,suggesting that its medicinal value in-depth research necessary.