两种抗凝药物方案治疗肺栓塞的疗效及经济学对比分析

Efficacy and economics analysis of two anticoagulant schemes in the treatment of inpatients with pulmonary embolism

目的:比较两种抗凝药物使用方案在肺栓塞患者治疗中的疗效及经济学差异。方法:采用回顾性调查方法,将2008年我院确诊为肺栓塞的住院患者,按治疗方案分为两组,Ⅰ组应用低分子肝素+华法林,Ⅱ组单纯应用低分子肝素,比较两组患者症状缓解率、血气指标改善情况等。结果:Ⅰ组(低分子肝素+华法林)患者咳嗽症状缓解率高于Ⅱ组(低分子肝素),差异有统计学意义(P<0.05);其他症状如胸闷伴呼吸困难、活动后气短、胸痛及咯血缓解率等两组间差异无统计学意义(P>0.05)。Ⅰ组药品费用、检查费、治疗费及总费用低于Ⅱ组,差异有统计学意义(P<0.05)。结论:两种方案对肺栓塞治疗的疗效相当,而低分子肝素联合应用华法林成本低于单纯应用低分子肝素。

Objective： To compare the curative effect and economic difference of two anticoagulant schemes for pulmonary embolism. Methods： A retrospective study was adopted. The inpatients with pulmonary embolism in 2008 in our hospital were divided into two groups. GroupⅠwere treated with low molecular heparin combined with warfarin, and groupⅡwere treated with low molecular heparin only. The rates of symptom alleviation and improvement in blood gas analysis were compared between two groups. Results： The alleviative rate of cough was higher in groupⅠthan in groupⅡ,and the difference was statistically signif icant （P 0.05）. While the remission rates of chest tightness with dyspnea, shortness of breath after activity, chest pain, haemoptysis and so on showed no significant difference between two groups （P 〉0.05）. The drugs expenditure, inspection fees, treatment fees and the total cost were lower in groupⅠthan in groupⅡwith significant difference （P 〈0.05）. Conclusion： There was no difference in curative effect between two groups, while the cost of low molecular heparin combined with warfarin was lower than that of single low molecular heparin.