防细菌耐药突变浓度理论文献计量分析

Bibliometric analysis of research papers on mutant prevention concentration

目的:采用文献计量学的方法分析防细菌耐药突变浓度理论(MPC)的研究进展,旨在为抗菌药物防耐药的深入研究提供参考。方法:电子检索Medline、Embase、Science Citation Index(SCI)、《中国医院知识仓库》、《中文科技期刊数据库》1999年1月–2010年3月国内外公开发表的文献,利用EndNote软件进行分类整理,然后对其发表年份、作者、研究机构、国别、研究内容等进行计量分析。结果:经各数据库检索去除重复文献后纳入国内外MPC相关文献270篇,其中,英文203篇,中文67篇。论著156篇,综述63篇,会议论文43篇。第一篇报道在1999年,2004年发表最多。加拿大的皇家大学医学院是发文量最多的机构,国内解放军总医院呼吸科发文量居第一位。从内容上看,关于MPC理论的研究以体外实验和动物实验为主,1篇文献是关于MPC理论临床验证的文章。研究最多的菌种是金黄色葡萄球菌、肺炎链球菌和铜绿假单胞菌。结论:MPC新理论的研究日益受到全球范围的广泛关注,研究内容愈加深入。

Objective： To analyze the recent advance on mutant prevention concentration （MPC） over the past 11 years with bibliometric approach for advanced research of MPC. Methods： Literatures were searched from Medline, Embase, Science Citation Index, China Hospital Knowledge database and VIP Chinese Journal database from Jan. 1999 to Mar. 2010. EndNote 2.0 was used to sort these articles and the bibliometric analysis was carried out in respect of published years, first authors, published institutions, countries and contents, etc. Results： A total of 270 articles were collected in our research, including 203 English articles and 67 Chinese papers. There were 156 original articles, 63 reviews and 43 conference articles. The first article of MPC was reported in 1999. The number of articles about MPC published in 2004 was the most. Canadian royal university hospital ranked the f irst place in all of institutions in terms of published articles relating to MPC, while the Chinese PLA General Hospital ranked the first place in China. From the aspect of content, most of the articles focused on the in vitro and animal study. One article reported the clinical validation of MPC hypothesis in tuberculosis patient. Most of researches focused on Staphylococci, Streptococcus pneumoniae and Pseudomonas aeruginosa. Conclusion： Many researchers pay more attention to MPC theory and the research will be studied deeper.