摘要
目的通过观察白细胞介素8、肿瘤坏死因子α与透明质酸的相关性,来探讨白介素8、肿瘤坏死因子α与肝纤维化的关系。方法用酶联免疫吸附试验,测定120例慢性肝病患者血清白细胞介素8和肿瘤坏死因子α水平,用放射免疫法测定血清透明质酸水平,并做相关性分析。结果病毒携带者组、活动性肝炎组、肝硬化组患者的血清白细胞介素8、肿瘤坏死因子α、透明质酸水平均高于对照组,差别有显著性,且随肝炎程度加重呈升高趋势。前两者与透明质酸的变化呈正相关。结论白介素8和肿瘤坏死因子α的水平和透明质酸呈正相关,可能与肝纤维化的形成有关。
Objective To analyze the relationship on IL-8,TNF-α with HA in chronic liver diseases. Methods Serum levels of IL-8 and TNF-α were measured by ELISA.The serum levels of HA was measured by RIA,in 120 patients with chronic liver diseases. Results The serum levels of IL-8,TNFαand HA were significantly higher than those in the control group,and increased with hepatitis progression. Conclusion The IL-8,TNF-α are related to liver cirrhosis formation.
出处
《河南科技大学学报（医学版）》
2010年第3期182-183,共2页
Journal of Henan University of Science & Technology:Medical Science
