腹腔免疫化疗预防胃癌术后腹腔复发的临床研究

Clinical study on the recurrence of peritoneal cavity with intraperitoneal chemo-immunotherapy after gastric cancer sugery.Hua Yawei,Zhang Jianzhe,Li Tian

目的评价腹腔免疫化疗对侵及浆膜的进行期胃癌根治术后预防腹腔复发的疗效。方法１９９２年１０月至１９９４年１２月对１９９例可切除的进行期胃癌病人随机分成治疗组和对照组。治疗组１０４例应用卡铂２００ｍｇ＋白介素Ⅱ２０～４０万单位加入生理盐水２００～３００ｍｌ进行多点腹腔穿刺注射，连用５周，４个月后重复。对照组９５例则常规给予优福定口服。结果治疗组和对照组３年生存率分别为６０６％、４５３％（Ｐ＜００１）。腹腔复发率分别为４８％、３４９％（Ｐ＜００１）。结论腹腔免疫化疗可预防侵犯浆膜的进展期胃癌术后腹腔复发，是一种方法简便，安全可行，副作用少。

Objective To evaluate the effect of preventing the recurrence of peritoneal cavity with intraperitoneal chemo-immunotherapy after resection of gastric cancer,which had penetrated the serosa and visceral peritoneum. Methods From October 1992 to December 1994,199 cases were devided into treatment group(group )and control group(group ).104 cases(group )were treated with intraperitoneal chemo-immunotherpy after resection of advance gastic cancer.200mg carboplatin and interleukin- (24)10\+5U in 200300ml 0\^9% sodium chloride were intraperitoneally injected every week for 5 times.After 4 months the aboro treatment were performed again.95 cases(group )as control were used to take tablets of UFT. Results The 3-year survival rate in group and group were 60\^6%,45\^3%(P<0\^01).The recurrence of peritoneal cavity in group and group were 4\^8%,34\^95%(P<0\^01). Conclusion This is a simple,safe,effective and repeated method with less adverse effect for preventing the recurrence of peritoneal cavity after resection of invaded theserosa from advanced gastric cancer.