血必净对急性胰腺炎患者血浆内皮素浓度的影响

Effect of Xuebijing injection on the microcirculation of patients w ith acute pancreatitis

目的:观察血必净对急性胰腺炎(AP)患者血浆内皮素(ET)浓度的影响,从而了解血必净对微循环的改善作用。方法:选择54例AP患者,其中,轻症急性胰腺炎(MAP)30例,重症急性胰腺炎(SAP)24例。将患者随机分为常规+血必净治疗组(A组)和常规治疗组(B组),各组均含SAP12例、MAP15例。同时,以健康志愿者20例作为对照组。以放射免疫法(RIA)测定血浆ET浓度。结果:重症急性胰腺炎患者血浆ET浓度为(153.47±9.52)ng/L,显著高于轻症急性胰腺炎患者的(90.71±10.34)ng/L(P<0.05)和对照组的(51.78±7.45)ng/L(P<0.05)。B组患者经常规治疗后ET水平与治疗前比较无显著性差异(P>0.05),A组治疗后血浆ET水平较治疗前明显下降[(63.37±8.54)ng/L,(108.56±9.21)ng/L](P<0.05)。A组患者平均住院天数为11.73±1.89d,明显短于B组的16.22±2.15d(P均<0.05)。结论:血必净注射液治疗AP可有效降低患者血浆中的ET含量,其对改善AP患者的微循环具有较好的效果。

Objective：To explore the changes of plasma endothelin（ET） as well as the effects of Xuebijing injection on themicrocirculation of patients with acute pancreatitis （AP）.Methods：A total of 54 patients with AP was divided into group A （n=27）and B （n=27）,treated with routine method（groupB） and Xuebijing injection added routine method （group A）,respectively.Another20 normal individuals were used as normal controls.The levels of plasma ET were measured by radioimmunoassay.Results：The levels of ET in patients with severe acute pancreatitis[（153.47±9.52）ng/L] were significantly higher than those in the cases with mild acute pancreatitis[（90.71±10.34）ng/L,P〈0.05] and normal controls[（51.78±7.45）ng/L,P〈0.05].After treatment,the levels of ET in group B were slightly decreased compared with those before treatment（P〉0.05）,while the levels of ET in group A were obviously decreased compared with those before treatment[（63.37±8.54）ng/L vs （108.56±9.21）ng/L,P〈0.05].The average in-hospital time（11.73±1.89d） of group A were significantly shorter than that of group B （16.22±2.15d,P〈0.05）.Conclusions：Endothelin is involved in the occurence and progress of microcirculation disorder in pathogenesis of AP.Xuebijing injection is effective in the treatment of AP.