肾病综合征患儿血清铜、锌、铁及白蛋白的测定

Determination of Serum Copper,Zinc and Iron Concentrations In the Children With Nephrotic Syndrome

目的：观察肾病综合征患儿血清铜、锌、铁含量。方法：采用原子吸收分光光度法测定肾病综合征患儿血清铜、锌、铁，并与正常对照组进行比较。结果：肾病综合征患儿血清铜、锌均低于正常组（Ｐ＜００１），血清铁略低于正常对照组，无显著性差异（Ｐ＞００５）。同时测定了３１例肾病综合征患儿经治疗尿蛋白转阴后血清铜、锌、铁含量，其中血清锌为１１２μｍｏｌ／Ｌ，较治疗前升高，且有极显著性差异（Ｐ＜００１），血清铜、铁与治疗前比较无显著差异（Ｐ＞００５）。结论：血清白蛋白的减少是肾病综合征患儿血清铜。

Objective:To observe the serum copper,zinc and iron concentrations in the children with nephrotic syndrome (NS). Methods:The serum copper,zinc and iron levels of children with NS were measured by atomic absorption spectrophotometry.Results:The serum levels of copper and zinc in NS group were significantly lower than normal group. The serum level of iron in NS group showed no significant differece from normal group.The serum copper,zinc and iron levels of 31 children with NS were measured again when their urine protein became negative after treatment,and found that serum zinc concentration was 11.2 μmol/L,significantly higher than that before treatment.The serum levels of copper and iron showed no significant difference before and after treatment.Conclusion:The decrease of serum albumin is the important factor responsible for low serum copper and zinc in the children with NS.