摘要
目的:探讨不同剂量阿托伐他汀对高脂血症患者颈动脉粥样斑块的消退作用及降脂疗效。方法:选用高脂血症伴颈动脉粥样斑块患者219例,按阿托伐他汀用药剂量不同分为3组:20mg组75例、10mg组71例和对照组73例,观察治疗6个月后Tc、TG、LDL-c及颈动脉斑块的变化。结果:①阿托伐他汀在改善血脂方面优于对照组(P<0.05或P<0.01),20mg组优于10mg组(P<0.05);②阿托伐他汀在治疗颈动脉粥样斑块方面明显优于对照组,20mg组优于对照组(P<0.05),20mg组优于10mg组(P<0.05)。结论:较大剂量阿托伐他汀可明显缩小颈动脉粥样斑块,有效降低血脂,从而降低心脑血管事件的发生,无明显不良反应。
Objective：To study the effect of different dose of atorvastatin on arteriosclerosis plaque of carotid artery and lipid-lowering in hyperlipidemic patients.Methods：219 patients with hyperlipidemic and atherosclerosis were divided into three groups.Respectively received atorvastatin 20mg qd（n=75） and 10mg qd（n=71） and no atorvastatin（n=73） for 6 months.The levels of TC,TG,LDL-C were detected.Color Dpppler echocardiography was used to measure intima-media thickness （ITM） of the common carotid artery.Results：①The effect of lipid-lowering in received atorvastatin group was better than no receive（P〈0.05或P〈0.01）,20mg/d group was better than 10mg/d group（P〈0.05）;②For reduced the arteriosclerosis plaque of carotid artery,20mg/d group was better than 10mg/d group（P〈0.05）,20mg/d group was better than no receive group（P〈0.05）.Conclusion：High-dose atorvastatin treatment can effectly reduced the arteriosclerosis plaque of carotid artery and hyperlipidemia.
出处
《医学信息（中旬刊）》
2010年第10期2926-2927,共2页
Medical Information Operations Sciences Fascicule
