克拉霉素干混悬剂体外抗菌活性的研究

THE STUDY ON IN VITRO ANTIBACTERIAL ACTIVITY OF CLARITHROMYCIN DRIED SUSPERISON

目的：探讨克拉霉素新剂型——干混悬剂的体外抗菌作用。方法：应用稀释法及临床分离所得的285株致病菌对克拉霉素干渴悬剂和阳性对照药红霉素进行体外抗菌活性的测定，并考查了细菌接种量，血清浓度和培养基pH值对克拉霉素干混悬剂最小抑菌浓度（MIC）的影响，同时测出受试药克拉霉素干混悬剂的杀菌曲线。结果：克拉霉素干混悬剂具有与红霉素相同的抗菌谱，对红霉素敏感的菌株其抗菌活性与红霉素基本相同，对耐红霉素的葡萄球菌、粪肠球菌等阳性球菌有一定的抗菌作用，但对大肠杆菌、克雷伯氏菌等阴性菌与红霉素抗菌作用不明显；在培养基pH偏碱条件下，其抗菌作用增强，血清浓度的改变对该药的抗菌作用影响不明显。杀菌曲线显示：克拉霉素干混悬剂对金葡球菌及化脓性链球菌的杀菌速度比红霉素快。结论：克拉霉素干混悬剂无论从其抗菌效果还是剂型改进方面均优越于红霉素，是一具有开发前景的新药。

In order to observe the in vitro antibactrial activites of clarithromycin dried suspension and erythromycin. Methods: The drugs against 285 clinical isolates were studied by the diluting method. The differ-ent on quantum of bacteria, serum concentration and pH of culture medium were also detected. Results: The re-sults indicated that the in vitro activity of clarithromycin dried suspension was the same as erythromycin. Both of the drugs are effective against erythromycin-sensitive Staph. spp. and Strep. spp. (MIC90 0. 125 mg/ml), and had also some effect on erythromycin-resistant bacteria. But there was no effect on Esch. coli and Kleb. p-neumoinae. The action of clarithromycin dried suspension was strong when pH was 8. 0, but was repressed when serum concentration was >75 %. Conclusion: The clarithromycin dried suspenaion is a new drug against bacteri a, and its antibacterial activity has been fully proved.