急性胰腺炎大鼠血浆ET/NO比值的变化及其与胰腺血流量的关系

Changes of plasma ET/NO ratio and their relationship with pancreatic blood flow during acute pancreatitis in rats

目的：探讨急性胰腺炎（ＡＰ）大鼠血浆ＥＴ／ＮＯ比值变化及其与胰腺血循环间的关系。方法：用５％牛磺胆酸钠溶液胆胰管注入，诱发大鼠急性出血坏死性胰腺炎（ＡＨＮＰ）模型。动态观察大鼠血浆内皮素（ＥＴ）水平、一氧化氮（ＮＯ）含量变化，及其与胰腺血流量（ＰＢＦ）、病理改变间内在联系。结果：ＡＨＮＰ大鼠早期存在显著胰腺缺血和血浆ＥＴ、ＮＯ的显著升高，ＥＴ／ＮＯ比值持续增加。结论：血浆ＥＴ、ＮＯ的改变及ＥＴ／ＮＯ比值增加，可能介导ＡＨＮＰ大鼠血循环紊乱发病过程。

Objective: To study the changes of plasma ET/NO ratio and their relationship with pancreatic blood flow during acute pancreatitis. Methods: The rat model of acute hemorrhagic necrotizing pancreatitis (AHNP) was established by injecting 5% sodium taurocholate into the bilepancreatic duct. The changes of plasma endothelin (ET) nitric oxide (NO) were dynamically determined and their relationship to the changes of pancreatic blood flow (PBF) and pancreatic pathology was also observed. Results: In the early stage of AHNP, pancreatic ischemia occurred and plasma level of ET and NO was significantly increased. Consequently ET/NO ratio was progressively increased. Conclusion: The increase of ET and NO level and ET/NO ratio in the plasma might play a part in the pathological changes of AHNP in rats.