异丙酚的麻醉强度测定

Determination of anesthetic potency of propofol

目的：观察异丙酚对安氟醚最低肺泡有效浓度（ＭＡＣ）及手术切皮无应激反应的ＭＡＣ（ＭＡＣ－ＢＡＲ）的影响。方法：ＡＳＡＩ－Ⅱ级择期手术病人３０例，随机分为两组，以手术切皮为疼痛刺激方法。异丙酚用３ｍｇｋｇ－１的诱导剂量加５３．８μｇｋｇ－１ｍｉｎ－１连续输注。结果：测得安氟醚ＭＡＣ为１．６０９Ｖｏｌ％，ＭＡＣ－ＢＡＲ为１．７３６Ｖｏｌ％，与经典值相对照，异丙酚对安氟醚ＭＡＣ没有明显影响，但能降低ＭＡＣ－ＢＡＲ３５．５％。结论：异丙酚镇痛作用很弱或没有镇痛作用，异丙酚应用后不必用高浓度吸入麻醉药即可阻断循环与内分泌反应，用ＭＡＣ－ＢＡＲ作麻醉强度指标，能显著减少或基本消除手术中的心血管及神经内分泌应激反应。

Objective: To investigate the effects of propofol on the minimum alveolar concentration (MAC) and MAC to blocking adrenergic responses (MACBAR) of enflurane to determine the anesthetic potency of propofol. Methods: Thirty patients were equally randomized into two groups. The initial surgical skin incision was used as the standard noxious stimulus for determination of MAC. Propofol with the dose of 3 mgkg-1 was injected and then continuously infused at a dose of 53.8 gkg-1min-1. Results: MAC and MACBAR of enflurane were 1.609Vol% and 1.736 Vol% respectively. Compared with those previously reported, propofol could not significantly influence MAC of enflurane but decrease MACBAR by 35.5%. FZConclusion: Propofol has no effects on enflurane's MAC but helpful for blocking the cardiovascular and neuroendocrine responses.