和胃口服液对大鼠胃分泌功能的影响

The Effects of Hewei Oral Liquid on Gastric Secretory Function of Rat

目的观察和胃口服液对大鼠胃分泌功能的影响。方法按Shay氏法造型，十二指肠给药，收集结扎4h后的胃液，以托资指示剂和酚酞二步满足法测定胃酸；以Mett氏改良法测定胃蛋白酶活性。结果和胃口服液能抑制幽门结扎大鼠胃液分泌量，降低总段排出量和胃蛋白酶排出量；对大鼠胃液的酸度无明显影响。结论和胃口服液有一定的抑制胃粘膜攻击因子的作用。

Aim Observe Hewei oral liquid's protective function on rats' gastric mucosa injury. Method Afterbeing fasted 48 hours, build a model of gastric mucosa injury with absolute ethyl alcohol, 0. 6N hydrochloric acid and 0.2N odium hydroxide, 3 hours before that feed the rats with Hewei oral liquid and normal saline,1 hour after building the model observe the indexes of the injury of gastric mucosa. 3 hours before using ab-solute ethyl alcohol feed Hewei oral liquid, after 1 hour and 2 hours separately, inject 2 groups of rats withindomethacin subcutaneously, 1 hour later, observe the indexes of gastric mucosa injury. Result Hewei o-ral liqiuid can effectively prevent gastric mucosa injury caused by such substances as absolute ethyl alcohol,strong acid and alkali which can produce acute necrosis, it gets more effective when it is used more, but this function can be partly stopped by indomethacin which is a repressor sythesized by endogenous PG. Conclu-sion Hewei oral liquid has an obvious protective function of cells, the mechanism of the function perhaps has something to do with its causing gastric mucosa to sythesize and release endogenous PG.