摘要
目的：通过皮层脑电（ＥＣｏＧ）的定量分析评价康脑灵（ＫａｎｇＮａｏＬｉｎ，ＫＮＬ）对缺氧状态下大鼠的脑保护作用。方法：用定量方法分析在体脑电在正常供气与停止呼吸情况下的变化，判断药物的脑保护作用。结果：ｉｇ康脑灵可以显著延长停止供气后脑电平均振幅到达最低点的时间，促进重新供气后脑电活动的完全恢复。这种作用在０６３ｇ·ｋｇ－１和１２６ｇ·ｋｇ－１间呈剂量依赖性，与对照组有极显著差异，与氟桂嗪组（２５ｍｇ·ｋｇ－１）无显著性差异。其中康脑灵１２６ｇ·ｋｇ－１组在缺氧２ｍｉｎ时脑电不完全消失。ｉｇ康脑灵可以不同程度地降低皮层脑电的平均振幅。结论：ｉｇＫＮＬ在一定剂量范围内有明显的抗脑缺氧的作用。
AIM: The neuroprotective effect of KNL(components:Llysine
monohydrochlorideVit B1Vit B6=900352) against acute iterative anoxia was studied with
quantitative analysis of electrocorticogram(ECoG). METHODS: Quantitative analysis method
was used to analyze the duration of disappearance of ECoG and its recovery, and, in turn, to
appraise the neuroprotective effect of KNL on anoxia. RESULTS: On the acute iterative anoxia
model of rats, KNL(063, 126 gkg-1 ig) was shown to markedly and dosedependently prolong the
time of ECoGs average amplitude reaching the lowest level or the isoelectric point in the 2min
anoxia group and promote the recovery of ECoG in the 3min anoxia group. The difference was
significant compared with the normal saline group(P<001) and insignificant compared with the
flunarizinepretreated (25 mgkg-1 ig) group(P>005). In the 2min anoxia group pretreated with 126
gkg-1 ig, ECoG did not reach the isoelectric point and the lowest average amplitude was 10
percent that of nomoxia. KNL at different doses decreased the average amplitude of ECoG in
different doses groups. CONCLUSION: KNL ig in certain range of doses has neuroprotective
effect on reiterate anoxia in rats.
出处
《药学学报》
CAS
CSCD
北大核心
1999年第6期415-418,共4页
Acta Pharmaceutica Sinica
关键词
康脑灵
皮层脑电
脑缺血
缺氧
脑保护
KNL
Llysine monohydrochloride
flunarizine
anoxia
electrocorticogram
