高血压、冠心病患者血浆组织因子及组织因子途径抑制物活性变化

Changes of TF and TFPI activities in patients with hypertension or coronary atherosclerotic heart disease

目的：观测高血压及冠心病患者血浆ＴＦ活性与ＴＦＰＩ活性的变化。方法：采用二步法测定血浆ＴＦ活性；以Ｓａｎｄｓｅｔ发色底物法测定ＴＦＰＩ活性。结果：高血压与冠心病患者血浆ＴＦ与ＴＦＰＩ活性均高于正常对照组（Ｐ＜０．０５）。结论：凝血功能亢进可能参与了高血压、冠心病形成，提示血浆ＴＦ和ＴＦＰＩ活性测定值可作为高血压、冠心病辅助性诊断指标。

Object: to investigate the changes of tissue factor(TF) and tissue factor pathway inhibitor(TFPI) activities in patients with hypertension or coronary atherosclerotic heart(CAH) disease. Methods: TF activity was measured by two stage assay, and TFPI activity was detected according to Sandset's method. Results: Plasma TF activity in both patients with hypertension and patients with CAH disease was higher than that of normal control( P <0.05). Conclusion: Hypercoagulative state may be involed in the pathogenetic processes of hypertension and CAH diseases. TF and TFPI activities have the likelihood to become the accessory diagnostic indexes for hypertension and CAH diseases.