血清白蛋白尿素氮肌酐水平与冠心病的相关性初探

Relationship of serum albumin,blood urea nitrogen and creatitine with coronary artery disease

目的:探讨冠状动脉粥样硬化性心脏病(冠心病)与白蛋白、尿素氮、肌酐水平的关系,为冠心病的预防、诊断、治疗提供依据。方法:采用病例-对照研究的方法,测定观察组和对照组的血清白蛋白、尿素氮、肌酐和血脂水平。结果:观察组TC、TG、SUA、Cr和BUN水平高于对照组,但Alb水平低于对照组(P<0.05),LDL和HDL水平无统计学意义。观察组的高TG、高SUA、低Alb、高Cr和高BUN均高于对照组(P<0.001)。TG与SUA呈正相关,与Alb呈负相关、LDL与SUA呈正相关(P<0.05)。结论:白蛋白、肾脏功能及血尿酸可能是高血压等传统因素之外的冠心病的不可忽视的危险因素之一。对上述因素进行早期检测,对冠心病患者的预防有重要意义。

Objective：To investigate the relationship of albumin,blood urea nitrogen and creatinine with coronary artery disease（CAD）.Methods：To use the case-control study.The level of serum albumin,blood urea nitrogen,creatinine and blood lipoprotein were tested in all patients.Results：The levels of total cholesterol,triglyceride,serum urea acid,creatinine,and blood urea nitrogen in CAD group were significantly higher than those in the control group（P0.001）.The level of serum albumin in CAD group was significantly less than that in the control group（P0.05）.Total cholesterol was positively correlated with serum urea acid and negatively correlated with albumin.Low density lipoprotein was positively correlated with serum urea acid（P0.05）.Conclusion：Albumin,renal function and serum urea acid should be the remarkable risk factors of CAD except the traditional factor like hypertension.Therefore,early detecting such factors has the important meaning to prevent coronary artery disease.