1Ueland PM, Refsum H, Stabler SP,et al.Total homocysteine in plasma of serum:Methods and clinical applications[J].Clin Chem, 1993,39(9) : 1764.
2Jacobsen DW, Gatautis V J, Green R, et al.Rapid HPLC determination of total homocysteine and other thiol in serum and plasma:sex differences and correlation with cobalamin and folate concentrations in healthy subjects[J].Clin Chem, 1994,40(5):873.
6Graham IM, Daly LE, Refsum H, et al.Plasma homocysteine as a risk factor for vascular disease[J].JAMA, 1997,277 : 1775.
7Nygard O, Nordrehaug JE, Rcfsum H,et al.Plasma homoeysteine levels and mortality in patients with coronary artery disease[J].N Engl J Med, 1997,337:230.
8Selhub J ,Jacques PF, Bostom AG, et al.Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis[J]. N Engl J Med, 1995,332:286.
9Manuel R, Malinow, Paul B, et al.Reduction of plasma homocyst(e)- ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease[J].N Engl J Med, 1998,338:1009.
10Soinio M, Marniemi J, Laakso M, et al.Elevated Plasma ho2 mocysteine level is an independent predictor of coronary heart disease event s in patient s wit h type 2 diabetes mellitus[J].Ann Intern Med, 2004,140(2):942100.
2Semenza GL. HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol, 201, 13(2): 167- 171
3Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell, 2001, 107(1): 43～54
4Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxiainducible factor lalpha expression by the epidermal growth factor/phosphatidylinositol3-kinase/PTEN/AKT/FRAP pathway in human prostate ancer cellsL Implications for tumor angiogenesis and therapeutics. Cancer Res, 200, 60(6): 1541 ～ 1545
5Jeong JW, Bae MK, Ahn MY, et al.Regulation and destabilization of HIFlalpha by ARD1-mediated acetylation. Cell, 2002, 11(5): 709～720
6Fukuda R, Hirota K, Fan F, et al.Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem, 2002, 277(41): 38205～ 38211
7Brahimi-Horn C, Berra E, Pouyssegur J. Hypoxia: The tumor' s gateway to progression along the angiogenic pathway. Trends Cell Biol, 2001, 11(11 ): S32 ～ S36
8Inoue M, Itoh H, Ueda M, et al.Vascular endothelial growth factor(VEGF) expression in human coronary atherosclerotic esions: Possible pathophysiological significance of VEGF in ession of therosclerosis.Circulation, 1998, (20): 2108 ～2116
9Zhao Q, Egashira K, Inoue S, et al.Vacular endothelial growth factor is necessary in the development of arteriosclerosis by recruiting/activating monocytes in a rat model of long-term inhibition of nitric oxide synthesis.Circulation, 2002, 105(9): 1110～1115
10Gorlach A, Diebold I, Schini-Kerth VB, et al. Thrombion activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase. Circ Res,2001, 89(1): 47～54.
