MCM5和Ki-67在乳腺癌组织中的表达及意义

MCM5 and Ki-67 expression in breast cancer tissues and its significance

目的:探讨微小染色体维持蛋白5(MCM5)和Ki-67基因蛋白在乳腺癌组织中的表达及意义。方法:用免疫组织化学SP方法对手术诊断的142例乳腺癌组织与40例正常乳腺组织中MCM5和Ki-67基因蛋白进行检测,分析其表达情况。结果:MCM5、Ki-67在乳腺癌与正常组织中皆有表达,乳腺癌组织的表达明显高于正常组(P<0.05)。MCM5表达和Ki-67表达呈正相关(相关系数r=0.486P=0.031)。MCM5表达与乳腺癌组织分级、临床分期、淋巴结转移有关(P<0.05)。Ki-67与临床分期、淋巴结转移有关(P<0.05)。结论:MCM5和Ki-67的表达与乳腺癌的发生、发展有关,可能成为新的乳腺癌肿瘤增生标志物。

Objective：To investigate the MCM5 and Ki-67 in breast cancer tissues and its significance.Methods：The immunohistochemical SP method was used to detect MCM5 and Ki-67 protein ion in 142 cases of breast cancer tissue,diagnosed by surgery,and 40 cases of normal breast tissue from August 2008 to January 2010 in our hospital.Their expression status was analyzed.Results：Both breast cancer and normal tissues had the expression of MCM5 and Ki-67,the expression of breast cancer tissue was significantly higher than that of the normal tissue （P0.05）.MCM5 expression and Ki-67 expression showed positive correlation（r= 0.486 P=0.031）.MCM5 expression was related with breast cancer grade,clinical stage,lymph node metastasis （P0.05）.Ki-67 was related with clinical stage,lymph node metastasis （P0.05）.Conclusion：MCM5 and Ki-67 expression is related with the occurrence and development of breast cancer, which may become the new markers of breast cancer tumor proliferation.