孕妇沙眼衣原体感染与妊娠结局及新生儿发病的关系

The Effect of Chlamydia Trachomatis Infection in Pregnant Women on Pregnant Outcome and Neonates

目的了解孕妇沙眼衣原体（ＣＴ）感染情况及感染后对孕妇妊娠结局及新生儿的影响。方法采用聚合酶链反应（ＰＣＲ）技术对产前检查的２７３例孕妇取宫颈分泌物进行ＣＴ检测，同时进行有关因素的调查，并追踪随访孕妇妊娠结局及新生儿情况。结果孕妇ＣＴ感染率为３５．９０％；孕妇ＣＴ阳性组异常妊娠结局（早产、流产）发生率（２４．７２％）高于ＣＴ阴性组（１２．２０％）（Ｐ＜０．０５），孕妇ＣＴ阳性组新生儿眼、肺部发病率（１７．９８％）高于ＣＴ阴性组（０．６１％）（Ｐ＜０．０１），在低体重儿发生率上，ＣＴ阳性组（１３．４８％）高于阴性组（４．８８％）（Ｐ＜０．０５）。结论孕妇中ＣＴ感染已相当普遍，并可引起不良妊娠结局。

Objective To determine the prevalence of chlamydia trachomatis (CT) in pregnant women and its effect on pregnant outcome and neonate. MethodsBZSpecimen of cervical swab were collected and detected for CT by polymerase chain reaction (PCR) method meanwhile relevant factors were investigated. Pregnant outcome and neonatal situation were also followed up. Results The infection rates of CT in pregnant women were 35.90%. The Incidence of abnormal pregnant outcome (premature delivery and abortion) was significantly higher in CT positive groups (24.72%) than that in negative groups (12.20%)(P<0.05). Incidence of neonatal conjunctivitis and pneumonia were significantly higher in CT positive groups (17.98%) than that of negative groups (0.61%) (P<0.01). There was statistically significant difference in the prevalence of low birth weight (<2 500g) between the two groups (13.48% versus 4.88%) (P<0.05), and mode of delivery also had influence on neonatal morbidity. Conclusion Prevalence of CT infection in pregnant women is rather common, and it may cause adverse pregnancy outcome.