食物特异性IgG抗体检测在变态反应性皮肤病中的应用

Detection of food-specific IgG antibodies in serum of patients with allergic dermatosis

目的探讨食物特异性IgG抗体检测在变态反应性皮肤病中的临床意义,为变态反应性皮肤病的病因诊断及防治提供参考依据。方法采用ELISA方法检测74例荨麻疹、63例过敏性紫癜、23例湿疹以及77例变应性皮炎患者血清中14种食物特异性IgG抗体。结果 237例变态反应性皮肤病患者中,食物特异性IgG总阳性率为67.1%,各组IgG阳性检出率差异无显著性(P>0.05)。4组变态反应性皮肤病患者的主要食物致敏源谱系既有相同性也有一定差异性,其中鸡蛋和牛奶是所有疾病组中检出阳性率最高的两种食物。食物不耐受患者中,对1、2种食物不耐受者居多。结论变态反应性皮肤病患者食物不耐受发生率较高,食物不耐受与变态反应性皮肤病具有密切相关性。食物特异性IgG抗体检测对常见变态反应性皮肤病的病因诊断、治疗和预防具有重要意义。

【Objective】To explore the clinical significance of food-specific IgG antibodies in serum of patients with allergic dermatosis and provide guiding instructions for diagnosis,treatment and prevention.【Methods】 Fourteen food-specific IgG antibodies in serum of 237 cases were determined by ELISA assay.【Resulits】The total positive rate of food-specific IgG was 67.1%.The positive rates were not significantly different among different groups（P 0.05）.The positive rates of egg and milk were the highest in all groups.【Conclusions】A higher positive rate of food-specific IgG was found in patients with allergic dermatosis.There was a close relationship between food intolerance and allergic dermatosis.Detection of food-specific IgG antibody in serum is of importance for diagnosis,treatment and prevention in allergic dermatosis.