糖链抗原125在心力衰竭中的作用

Significance of carbohydrate antigen 125 detection in the patients with heart failure

目的探讨心力衰竭患者糖链抗原125(CA125)血浓度的变化情况及其临床意义。方法分别在25例正常人和65例治疗前、后出现心力衰竭的患者(按NYHA心功能分级分为Ⅱ～Ⅳ级)中,测定CA125和B型钠尿肽(BNP)浓度。结果治疗前心力衰竭患者血CA125浓度为(74.92±24.92)nmol/L,明显高于正常对照组(20.77±13.64)nmol/L,P<0.01;BNP浓度([399.48±286.60)nmol/L]亦明显高于正常对照组([64.45±42.32)nmol/L],P<0.01。治疗后心力衰竭患者血CA125浓度为(45.76±16.47)nmol/L,明显低于治疗前水平,P<0.01;治疗后心力衰竭患者BNP浓度([184.98±99.33)nmol/L]亦明显低于治疗前水平,P<0.01,且CA125浓度与心功能分级间存在正相关性(r=0.5629,P<0.01)。CA125浓度与BNP水平也存在正相关性(r=0.5137,P<0.01)。结论心力衰竭患者血清肿瘤标志物CA125含量可明显升高,经治疗症状好转后又能迅速下降。而且,CA125浓度与BNP浓度、患者病情严重程度有一定相关性,其变化程度对评价心功能的程度和转归可能有一定的参考价值;另外,CA125浓度亦可见于非恶性肿瘤性疾病。

【Objective】To investigate the changes and significance of tumor marker carbohydrate antigen 125（CA125） in the patients with heart failure.【Methods】The serum concentration of CA125 and plasma B-type natriuretic peptide（BNP） were measured in 25 normal people as control group and in 65 patients with heart failure（HF）（according to the criterion of NYHA classes,HF patients were Ⅱ class～IV class heart function）.【Results】The blood concentration of CA125 and the BNP in heart failure groups were higher than that in control group respectively（74.92±24.92）nmol/L,（20.77±13.64）nmol/L（P 0.01）;and（399.48±286.60）nmol/L,（64.45±42.32）nmol/L（P 0.01）.After the treatment,the blood concentration of CA125 and the BNP in heart failure groups were lower than that before the treatmentl group respectively（45.76±16.47）nmol/L,（P 0.01）;and（184.98±99.33）nmol/L,（P 0.01）.There were positive relationship between the blood concentration of CA125 and the level of heart function in heart failure groups（r =0.5629,P 0.01）.There were positive relationship between the blood concentration of CA125 and BNP（r =0.5137,P 0.01）.【Conclusion】The serum concentration of CA125 may increase in the HF patients,but it may decrease after the effective treatment.There are some positive relationship between the blood concentration of CA125 and the blood concentration of BNP,the severity of heart failure.The changes of the serum CA125 is of valuable for evaluating the heart function and the prognosis of heart failure patients.The serum CA125 concentration could also been found higher levels in other diseases besides malignant.