慢性心力衰竭患者血浆N-末端脑利钠肽与内皮素的相关性

Correlation of plasma NT-proBNP and ET levels in patients with chronic heart failure

目的测定慢性心力衰竭(CHF)患者血浆N-末端脑利钠肽(NT-proBNP)和内皮素(ET)的含量,探讨二者的相关性及临床意义。方法选取58例CHF患者及20例心功能正常者,用ANALYTICS E170光电免疫发光仪对血浆NT-proBNP的含量进行测定,用放射免疫法测定血浆ET水平,并分析二者的相关性。结果①CHF患者的血浆NT-proBNP和ET含量均明显高于心功能正常组(P依次为<0.001,<0.05);②CHF患者血浆NT-proBNP与ET水平呈正相关(r=0.696,P<0.001)。结论慢性心力衰竭患者血浆NT-proBNP水平明显升高,并与ET水平呈正相关,提示NT-proBNP和ET在CHF的发生、发展中起重要作用。

【Objective】 To measure plasma N-terminal pro-brain natriuretic peptide（NT-proBNP） and endothelin（ET） concentrations in patients with chronic heart failure（CHF）,and to study their correlation and clinical significance.【Methods】 A total of 78 subjects were divided into two groups：CHF patient group（58 cases）,and control group（20 cases）.Plasma NT-proBNP concentration was measured by ANALYTICS E170 Immunity Analyzer,plasma ET concentration was measured with radioimmunoassay,and to study their correlation was investigated.【Results】①Plasma NT-proBNP and ET concentrations increased in CHF patients compared with those of control group（P 0.001,0.05 by turns）;Plasma NT-proBNP concentrations were correlated with ET in CHF patients（r =0.696,P 0.001）.【Conclusion】The results suggest that the levels of plasma NT-proBNP and ET may possess important significance in development of CHF.