非洛地平与氢氯噻嗪对高血压患者心脏舒张功能的影响

Effect of felodipine and hydrochlorothiazide on cardiac diastolic fuction of patients with hypertension

目的观察氢氯噻嗪与非洛地平对原发性高血压患者心脏舒张功能的改善作用。方法 160例在该院门诊就诊的原发性高血压患者随机分成两组,氢氯噻嗪组及非洛地平组,两组经过2周的药物洗脱期后,分别给予40周的非洛地平(5～10mg/d)或氢氯噻嗪(12.5～25.0mg/d)治疗,对治疗前后的血压情况及心脏彩色B超进行监测。结果两组服药后血压及心脏舒张功能较服药前有明显改善(P<0.05),两组之间血压降低程度及心脏舒张功能改善程度无统计学意义(P>0.05)。结论氢氯噻嗪与非洛地平在降压效果相同时对心肌舒张功能的改善作用是一致的。

【Objective】 To observe the effect of felodipine and hydrochlorothiazide on cardiac diastolic function of patients with hypertension.【Methods】 160 patients with HBP were stratified by random,contrastive as-signed to felodipine group（5～10 mg/d of felodipine for 40 weeks）,hydrochlorothiazide group（12.5～25.0 mg/d of hydrochlorothiazide for 40 weeks）.The blood pressure and cardiac diastolic function before and after treatment were detected.【Results】 After treatment of drugs,the levels of blood pressure were significantly lower and cardiac diastolic function were improved（P 0.05）.【Conclusion】 Hydrochlorothiazide and felodipine have same effect on improving cardiac diastolic function when the effecteviness of reducing blood pressure is the same.