心肌缺血再灌注损伤进展

Advances in Research on Ischemia-reperfusion Injury

缺血-再灌注损伤指的是在组织器官缺血恢复血流后,不仅没使组织器官功能恢复,反而使缺血所致的功能和代谢障碍及结构破坏进一步加重,甚至出现不可逆损伤的现象。研究最多的就是心肌缺血-再灌注损伤。随着溶栓、冠状动脉搭桥术、经皮冠状动脉内成形术等血管再灌注疗法通过恢复缺血组织的供血有效挽救濒死心肌。但是再灌注受缺血组织血管再通时间限制并存在再灌注损伤等问题,因此随着新的再灌注技术在l临床广泛应用,防治心肌缺血-再灌注损伤成为冠心病治疗亟待解决的关键问题之一。

Ischemia - reperfusion injury refers to the restoration of blood flow in isehemic tissues and organs. It does not make not only tissue and organ function recovery but also further aggravation of the metabolic disturbances and structural breaks induced by ischemia, and even the phenomenon of irreversible damage occurs. Current research trend is myocardial ischemia - reperfusion injury （MIRI）. Extreme myocardium is saved effectively by restoring the blood supply in ischemic tissue with thrombolysis, coronary artery bypass surgery, percutaneous coronary intervention and other vascular reperfusion therapy. However reeanalization in ischemic tissue is constrained by time and there is reperfusion injury issues. So with the new reperfusion techniques widely used in clinical practice MIRI becomes the key problem to be solved in the prevention of coronary artery disease.