真核因子NF-κB与脑缺血预处理

Nuclear Factor NF-κB and Cerebral Ischemic Preconditioning

真核因子NF-κB是一种广泛存在于真核细胞内可将信息从胞浆传至细胞核并引起相应基因表达的重要转录因子。NF-κB调控许多基因的表达,在突触信号转导、神经塑形、神经发育和神经变性、免疫、应激反应、炎症和细胞凋亡等方面具有独特作用。脑缺血预处理即给予短暂亚致死量缺血可对随后的长时间致死性缺血损伤产生耐受。脑缺血预处理可能是通过抑制NF-κB在脑缺血损伤中的过度激活,介导NF-κB一系列相关级联反应如:炎性反应、细胞凋亡、氧化应激、兴奋性谷氨酸、信号通路转导改变发挥脑保护作用。

NF -κB is an important transcription factor which is widely present in eukaryotic cells. NF-κB aslo controls the large - scale geue expression, and has a unique role in synaptic signal transduction, neural remodeling, neural development and neurodegenenation, immunity, stress response, inflammation, apoptosis and so on. Ischemic preconditioning gives the brain a brief sublethal ischemia which causes cerebral ischemic conditioning to resist the subsequently lethal ischemic injury in a long time. Mechanism of cerebral protection may depend on two methods. The one method is by suppressing the overactivation of NF-κB in cerebral ische- mia. The other can mediate a series of related cascade reaction about NF-κB, such as inflammatory response, apoptosis, oxidative stress, excitatory glutamate and change of signaling transduction pathway.