青霉素氧化产物的鉴别及其转化方法

Structural determination of penicillin G oxidation productand transformation method

用过氧乙酸氧化青霉素Ｇ钾工业盐得到一个不同于正常熔点（ｍｐ１６２～１６４℃）的低熔点（ｍｐ１００～１０２℃）氧化产物。薄层层析、高效液相色谱分析、ＩＲ、１Ｈ－ＮＭＲ、ＦＡＢ－ＭＳ、热重分析和元素分析的研究结果表明，此氧化产物为带两个结晶水的青霉素Ｇ亚砜。本文对带结晶水的青霉素Ｇ亚砜转化为无水青霉素Ｇ亚砜进行了研究。本文为青霉素Ｇ亚砜中间体质量标准的确定提供依据，确保得到合格的青霉素Ｇ亚砜。

Penicillin G is oxidized by peracetic acid, occasionally a low melting point product was obtained. From TLC, HPLC, its physicalchemical properties, IR, 1 HNMR, FABMS, TGA and element analysis, it was identified to be penicillin sulfoxide dihydrate. Methods to transform penicillin sulfoxide dihydrate to anhydrous penicillin sulfoxide were proposed.