摘要
采用微生物杯碟法测定甲磺酸左氧氟沙星大鼠组织分布和血清蛋白结合率，测定口服给药后１０ｍｉｎ、３０ｍｉｎ和４ｈ心、肺、肝、脾、肾、肠、脂肪、肌肉、子宫、睾丸、脑和血组织药物浓度，结果表明３０ｍｉｎ的组织药物浓度为最高，大鼠血清蛋白结合率为５７．８８±２．３１％。
We determined the distribution in rat tissues and serum protein binding rate of levofloxacin mesylate (MSALVLX). 10min, 30min and 4h after orally administered with MSALVLX at a dose of 20 mg/kg, rats were killed. Concentrations of MSALVLX in heart, lung, liver, spleen, kidney, intestines, fat, flesh, uterus, testicle, brain and blood respectively were determined. Results showed that concentration of 30min was the highest. The rat serum protein binding rate of MSALVLX is 57.882.31%.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1999年第3期208-210,共3页
Chinese Journal of Antibiotics
关键词
组织分布
蛋白结合率
利得星
MSALVLX
Levofloxacin mesylate (MSALVLX)
Tissue distribution
Serum protein binding rate
