摘要
目的探讨株洲地区女性人乳头瘤病毒(HPV)感染及其亚型分布状况,为HPV感染和宫颈癌的防治提供理论依据。方法采用核酸分子导流杂交法检测株洲地区2009年1月-2010年1月2 186例女性门诊患者HPV DNA,并对其亚型感染分布情况进行比较。结果株洲地区2 186例女性患者共检出HPV阳性902例,阳性率为41.26%(902/2 186),21种亚型均被检出。902例阳性样本中,HPV单一感染者587例,占65.08%(587/902);多重感染者314例,以二重感染为主,269例,占多重感染总数的85.67%(269/314),此外还检测出1例比较罕见的九重感染病例(HPV6、16、39、42、51、52、58、66、CP8304)。结论调查人群HPV感染率具有一定的区域性,HPV-52、11型可能是株洲地区妇女较易感染的亚型,值得重视。
Objective To explore human papillomavirus（HPV） infection and the distribution of genotypes of HPV in the areas of Zhuzhou,and to provide a theoretical basis for therapy and prevention of HPV infection. Methods With DNA hybridization genotyping technique,21 HPV DNA genotypes were detected in 2,186 female outpatients in Zhuzhou from January,2009 and January,2010.And the distribution of genotypes of HPV was analyzed. Results All of the 21 HPV subtypes were detected,and the HPV-positive rate was 41.26%（902/2,186）.The total single infection rate was 65.08%（587/902）.Two-type co-infection was prevalent,with the infection rate of 85.67%（269/314）.In addition,one patient with multiple-infection（HPV6,16,39,42,51,52,58,66, and CP8304） was detected. Conclusions HPV infection and multiple-infection are prevalent among the investigated population.Women in Zhuzhou have the higher risk of infection with HPV52 and 11,which indicates the specificity of HPV infection.
出处
《实用预防医学》
CAS
2010年第9期1751-1753,共3页
Practical Preventive Medicine
关键词
人乳头瘤病毒
基因型
分布
Human papillomavirus
Genotype
Distribution
