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皮质发育畸形致痫机制的分子遗传基础

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摘要 癫痫(epilepsy)是神经科常见的反复发作性慢性脑功能障碍性疾病。皮质发育畸形(MCD)是其常见的病因,癫痫患者大都为散发病例,然而通过对一些遵循孟德尔遗传规律的罕见家族进行研究证明,基因在MCD所致癫痫的致痫机制中具有非常重要的作用。如今,皮质发育畸形致痫机制中的分子遗传基础已成为国内外的研究热点。本文主要综述MCD的临床分类并探讨基因在各类MCD致痫机制中的作用及分子遗传基础,为癫痫的临床治疗提供新的思路。
作者 黄锦聪 林元相 康德智
机构地区 福建医科大学附属第一医院神经外科
出处 《国际神经病学神经外科学杂志》 2010年第4期328-332,共5页 Journal of International Neurology and Neurosurgery
基金 福建省教育厅科技项目B类(JB08110) 福建省高校新世纪优秀人才支持计划(NCETFJ-0702)
关键词 癫痫 皮质发育畸形 致痫机制 基因 分子遗传基础
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献16

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二级参考文献21

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国际神经病学神经外科学杂志
2010年 第4期

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