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MLL基因重排阳性儿童急性白血病的临床和实验研究进展 被引量：3

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摘要 11q23染色体异常是造血系统恶性肿瘤中的常见改变，此异常导致位于11q23的混合谱系白血病（Mixed lineage leukemia，MLL）基因发生重排。此类白血病具有独特的临床和生物学特征，对常规化疗不敏感，完全缓解率低，生存期短^[1]。目前WHO在对白血病的重新分类中将其单独列为11q23／MLL白血病。
作者 高超 李志刚 崔蕾 吴敏媛
机构地区 首都医科大学附属北京儿童医院血液病中心
出处 《中华血液学杂志》 CAS CSCD 北大核心 2010年第9期641-643,共3页 Chinese Journal of Hematology
基金 国家科技支撑计划课题（2007BA104B03） 北京市科技计划（D0905001040431） 北京市科技新星计划（2005B06）
关键词 MLL基因重排 儿童急性白血病 11q23染色体异常 实验研究 临床 造血系统恶性肿瘤 混合谱系白血病 阳性
分类号 R733.7 [医药卫生—肿瘤]
  • 相关文献

参考文献24

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  • 2Mitterbauer-Hohendanner G,Mannhalter C.The biological and clinical significance of MLL abnormalities in haematological malignancies.EurJ Clin Invest,2004,34 Suppl 2:12-24.
  • 3Hess JL.MLL:a histone methyltransferase disrupted in leukemia.Trends Mol Med,2004,10:500-507.
  • 4Ernst P,Fisher JK,Avery W,et al.Definitive hematopoiesis requires the mixed-lineage leukemia gene.Dev Cell,2004,6:437-443.
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同被引文献39

  • 1N L Harris,E S Jaffe,J Diebold,G Flandrin,H K Muller-Hermelink,J Vardiman,T A Lister,C D Bloomfield,张凤奎,郝玉书.世界卫生组织(WHO)造血与淋巴组织肿瘤分类方案:临床顾问委员会会议报告[J].白血病．淋巴瘤,2001,10(3):171-181. 被引量：20
  • 2吴学东,李春富,何岳林,杨明,张玉明,冯晓勤,藤志丽,孙树梅,钱新华.儿童急性淋巴细胞白血病南方ALL99方案临床疗效分析[J].中华儿科杂志,2005,43(12):890-893. 被引量：5
  • 3顾龙君.儿童急性淋巴细胞白血病诊疗建议(第三次修订草案)[J].中华儿科杂志,2006,44(5):392-395. 被引量：472
  • 4Walker DM,Fisher BT,Seif AE,et al. Dexrazoxane use in pedi-atric patients with acute lymphoblastic or myeloid leukemia from1999 and 2009 :Analysis of a national cohort of patients in thepediatric health information systems database[J]. Pediatr BloodCancer,2013,60(4) :616-620.
  • 5Ezoe S. Secondary leukemia associated with the anti-cancer agent,et-oposide,a topoisomerase fl inhibitor[J].Int J Environ Res PublicHealth,2012,9(7) :2444-2453.
  • 6Bandele OJ . Osheroff N. Bioflavonoids as poisons of human to-poisomerase II alpha and Q beta[J].Biochemistry,2007,46(20):6097-6108.
  • 7Chowdhury T,Brady HJ. Insights from clinical studies into therole of the MLL gene in infant and childhood leukemia[J].BloodCells Mol Dis,2008,40(2) :192-199.
  • 8Duhoux FP,Ameye G,Libouton JM.et al. The t( 11 ; 19) (q23 ;p13) fusing MLL with MY01F is recurrent in infant acute mye-loid leukemias[J].Leuk Res,2011,35(9) :e171-e172.
  • 9Tomizawa D,Koh K,Sato T,et al. Outcome of risk-based thera-py for infant acute lymphoblastic leukemia with or without anMLL gene rearrangement,with emphasis on late effects:a finalreport of two consecutive studies,MLL96 and MLL98,of the Ja-pan Infant Leukemia Study Group[J],Leukemia,2007,21(11):2258-2263.
  • 10Mcclendon AK,Osheroff N. DNA topoisomerase H ,genotoxici-ty,and cancer[J],Mutat Res.2007,623(1-2):83-97.

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中华血液学杂志
2010年 第9期

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