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基质相互作用分子1在炎性免疫细胞中的作用 被引量：3

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摘要 近年来基质相互作用分子（stromal interaction molecule,STIM）成为钙库调控的钙内流（store operated calcium entry,SOCE）研究中的一个热点,有STIM1和STIM2两种亚型,STIM1与钙库调控的钙通道（store operated calcium channel,SOC）激活高度相关,这在Roos等[1]及Liou等[2]的实验中得到证实,而STIM2在HEK293,A7rR5细胞研究中发现对SOC有抑制作用.SOC广泛分布于细胞膜上,以非兴奋性细胞为主,是胞外Ca2＋内流的主要通道之一,也称为Ca2＋释放激活的钙通道（Ca2＋release-activated Ca2＋channels,CRAC）.
作者 黎艳红 刘毅
机构地区 泸州医学院附属医院风湿免疫科 四川大学华西医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2010年第9期634-636,共3页 Chinese Journal of Rheumatology
基金 基金项目：国家自然科学基金（30972746）
关键词 炎性免疫细胞 相互作用 分子 基质 CHANNEL HEK293 CA2+ 钙通道
分类号 R686 [医药卫生—骨科学]
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参考文献17

  • 1Roos J,DiGregorio PJ,Yeromin AV,et al.STIM1,an essential and conserved component of store-operated Ca2+ channel function.J Cell Biol,2005,169:435-445.
  • 2Liou J,Kim ML,Heo WD,et al.STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.J Curr Biol,2005,15:1235-1241.
  • 3Manji SS,Parker NJ,Williams RT,el al.STIM1:a novel phosphoprotein located at the cell surface.J Biochim Biophys Acta,2000,1481:147-155.
  • 4Mercer JC,DeHaven WI,Smyth JT,et al.Large store-operated calcium-selected currents due to co-expression of orai 1 or orai 2 with the intracelullar calcium sensor,ST1M1.J Biol Chem,2006,281:24979-24990.
  • 5Gwack Y,Srikanth S,Feske S,et al.Biochemical and functional characterization of orai proteins.J Biol Chem,2007,282:16232-16243.
  • 6Matzner N,Zemtsova IM,Xuan NT,et al.Ion channels modulating mouse dendritic cell functions.J Immunol Rev,2008,181:6803-6809.
  • 7Lewis S,Gwack Y,Prakriya M,et al.A mutation in orail 1 causes immune deficiency by abrogating CRAC channel function.J Nature,2006,441:179-185.
  • 8Braun A,Gessner JE,Varga-Szabo D,et al.STIM1 is essential for Fc receptor activation and autoimmune inflammation.J Blood,2009,113:1097-1104.
  • 9Feske S,Prakriya M,Rao A,et al.A severe defect in CRAC Ca2+channel activation and altered K+ channel gating in T cells from immunodeficient patients.J Exp Med,2005,202:651-662.
  • 10Lioudyno MI,Kozak JA,Penna A,et al.Orail and STIM1 move to the immunological synapse and are up-regulated during T cell activation.J PNAS,2008,105:2011-2016.

同被引文献26

  • 1张洁霞,郑丽霞,毛小玲.中药卡宁对肺癌患者外周血bcl-2表达的影响[J].山东医药,2006,46(22):14-15. 被引量：3
  • 2夏义平,崔天盆,吴健民.Tim基因家族及其与自身免疫性疾病和过敏性疾病的关系[J].医学分子生物学杂志,2006,3(5):357-360. 被引量：3
  • 3许朝旭,张桂梅,黄波,冯作化.膜型Tim-3分子促进荷瘤小鼠抗肿瘤免疫应答的研究[J].医学分子生物学杂志,2007,4(3):200-203. 被引量：6
  • 4Nagahara K, Arikawa T, Oomizu S,et al. Galeetin - IncreasesTim - 3 - dendritic ceils and CD8T cells and enhances antitu- mot immunity via galeetin - 9 - Tim - 3 interactions[J]. J lm- munol,2008,181(11) :7760 - 7769.
  • 5Zoltan Wiener,Barbara Kohalmi,Peter Pocza. TIM- 3 is ex- pressed in mele, noma cells and is upregulated in TGF - beta stimulated masteeils[J]. J Invest Dermatol, 2007,127 (4) : 906 - 914.
  • 6Hanstings WD,Anderson DE,Kassam N,et al. Tira - 3 is ex pressed on activated CD( + ) TCells and regulates Thl and Th17 cytokines[J]. Eur J Irnmunol,2009,39(9):2492 - 2501.
  • 7Lee SO, Jeong YJ, Kim M, et al. Suppression of PMA- in duced tumor cell invasion by capillarisin via the inhitition of NF- kappa B- dependent MMP - 9 expression[J]. Biochem Biophys Res Commun,2008,366(4) :1019 - 1024.
  • 8Potier M, Gonzalez J C, Motiani R K, et al. Evidence for stim1- and orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: Role in proliferation and migration[J]. Faseb J, 2009, 23(8) :2425 -37.
  • 9Yang S, Zhang J J, Huang X Y. orai1 and stim1 are critical for breast tumor cell migration and metastasis [J]. Cancer Cell, 2009, 15(2): 124 - 34.
  • 10Irifune K, Yokoyama A, Sakai K, et al. Adoptive transfer of Thelper cell type 1 clones attenuates an asthmatic phenotype in mice [J]. Eur Respir J, 2005, 25 ( 4): 653 - 9.

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中华风湿病学杂志
2010年 第9期
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