期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

代谢组学及其在类风湿关节炎研究中的应用 被引量：1

原文传递
导出
摘要 代谢组学是继基因组学、转录组学、蛋白质组学后出现的以定量描述生物体内代谢物多参数变化为目标的新兴＂组学＂,是系统生物学的组成部分.机体代谢产物的水平是由代谢途径中所有酶的活性及作用于这些酶的效应物决定的,与机体的生理、病理、外环境状态密切相关.
作者 陈哲 涂胜豪 胡永红
机构地区 华中科技大学同济医学院附属同济医院中西医结合科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2010年第9期638-641,共4页 Chinese Journal of Rheumatology
关键词 代谢组学 类风湿关节炎 系统生物学 应用 体内代谢物 蛋白质组学 基因组学 转录组学
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献13

  • 1Horning MG,Murakami S,Horning EC.Analyses of phospholipids,ceramides,and cerebrosides by gas chromatography and gas chromatography mass spectrometry.Am J Clin Nutr,1971,24:1086-1096.
  • 2Nicholson JK,Lindon JC,Holmes E.Metabonomics:understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.Xenobiotica,1999,29:1181-1189.
  • 3Fiehn O.Metabolomics-the link between genotypes and phenotypes.Plant Mol Biol,2002,48:155-171.
  • 4Tailor J,King RD,Ahmann T.Application of metabolomics to plant genotype discrimi(n)ation using statistics and machine learning.Bioinformatics,2002,18:S241-S248.
  • 5Nicholson JK,Connelly J,Lindon JC,et al.Metabonomics:a platform for studying drug toxicity and gene function.Nat Rev Drug Discov,2002,1:153-161.
  • 6Naughton D,Whelan M,Smith EC,et al.An investigation of the abnormal metabolic status of synovial fluid from patients with rheumatoid arthritis by high field proton nuclear magnetic resonance spectroscopy.Febs Lett,1993,317:135-138.
  • 7Naughton DP,Haywood R,Blake DR,et al.A comparative evaluation of the metabolic profiles of normal and inflammatory kneejoint synovial fluids by high resolution proton NMR spectroscopy.Febs Lett.1993,332:221-225.
  • 8Duffy JM,Grimshaw J,Guthrie DJ,et al.1H-nuclear magnetic resonance studies of human synovial fluid in arthritic disease states as an aid to confirming metabolic activity in the synovial cavity.Clin Sci(London),1993,85:343-351.
  • 9Meshitsuka S,Yamazaki E,Inoue M,et al.Nuclear magnetic resonance studies of synovial fluids from patients with rheumatoid arthritis and osteoarthritis.Clin Chim Acta,1999,281:163-167.
  • 10Claxson A,Grootveld M,Chander C,et al.Examination of the metabolic status of rat air pouch inflammatory exudate by high field proton NMR spectroscopy.Biochim Biophys Acta,1999,1454:57-70.

同被引文献27

  • 1尹崑,卫小春.关节液中多糖含量与关节软骨损伤的关系[J].实用骨科杂志,2006,12(3):216-219. 被引量：9
  • 2毛煜,袁伯俊.代谢组学的研究现状与展望[J].中国新药杂志,2007,16(13):1005-1010. 被引量：6
  • 3Hinman RS, Crossley KM. Patellofemoral joint osteoarthritis : An im- portant subgroup of knee osteoarthritis. Rheumatology ( Oxford, Eng- land) , 2007, 46 (7): 1057 -1062.
  • 4Felson DT. Osteoarthritis: new insights. Part 1 : the disease and its risk factors. Ann Intern Med, 2000, 133 (8):635 -646.
  • 5Atherton HJ, Jones OA, Malik S, et al. A comparative metabolic study of NHR - 49 in Caenorhabditis elegans and PPAR - alpha in the mouse. FEBS Letters, 2008, 582 (12):1661 -1666.
  • 6Ellis DI, Dunn WB, Griffin JL, et al. Metabolic fingerprinting as a diagnostic tool. Phammcogenomics, 2007, 8 (9): 1243 - 1266.
  • 7Weckwerth W. Metabolomics: Methods and Protocols. Totowa: Hu- manaPress Inc, 2007, Preface.
  • 8Dettmer K, Aronov PA, Hammock BD. Mass spectrometry based metabolomics. Mass Spectrom Rev, 2007, 26 (l) : 51 - 81.
  • 9Lamers RJ, van Nesselrooij JH, Kraus YB, et al. Identification of an urinary metabolite profile associated with osteoarthritis. Osteoar- thritis Cartilage, 2005, 13 (9) : 762 - 768.
  • 10LI X, Yang SB, Qiu YP, et al. Urinary metabolomics as a potential- ly novel diagnostic and stratification tool for knee osteoarthfitis. Metabolomics, 2010 (6) : 109 - 118.

引证文献1

二级引证文献2

中华风湿病学杂志
2010年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部