双膦酸盐的名称及其使用情况的调查研究

Investigations of the names and uses of bisphosphonates

目的了解双膦酸盐的名称在国内的使用情况和存在问题。方法选择国内唯一的骨质疏松专业期刊《中国骨质疏松杂志》为调查对象,采用人工查找其使用了双膦酸盐名称的文章进行登记分析。登记范围限于使用了双膦酸盐在国内使用的四种名称,即"双膦酸盐"、"二膦酸盐"、"双磷酸盐"及"二磷酸盐"的文章。结果《中国骨质疏松杂志》从1995年8月至2009年7月共出版79期,刊载文章2076篇,其中使用了双膦酸盐四种名称的147篇。在这147篇文章中,使用一种双膦酸盐名称的126篇,使用两种或三种双膦酸盐名称的21篇。在126篇只用一种双膦酸盐名称的文章中,使用"双膦酸盐"的64篇(50.8%)、"二膦酸盐"的35篇(27.6%)、"双磷酸盐"的8篇(6.35%)、"二磷酸盐"的19篇(15.1%)。从2004年起,名称"双膦酸盐"的使用突然较大增加,但以后又停滞不前。与此同时,使用两种或三种双膦酸盐名称的文章不但未减少,反而略有增加。结论双膦酸盐名称在国内的使用仍处于紊乱状态,实现统一使用"双膦酸盐"这一名称还有很大困难。

Objective To understand the uses of the names of bisphosphonates and existing problems in China. Methods Chinese Journal of Osteoporosis, the unique special periodical osteoporosis journal in China, was selected for study. Manual screening was using to record articles that applied names of bishosphonates in four types,namely bisphosphonate, diphosphonate,bisphusphate, and diphosphate, Results From August 1995 to July 2009, Chinese Journal of Osteoporosis published 79 issues with 2076 articles. Among the 2076 articles, there were 147 articles that used one of the four names of bisphosphonates. Of the 147articles,126 articles used only one name of bisphosphonates, and 21 articles used two or three names of bisphosphonates. Of the 126 articles that used only one name of bisphosphonates, 64 articles used bisphosphonate （50.8%）, 35 articles used diphosphonate （27.6%）, 8 articles used bisphosphate （6. 35% ） ,and 19 articles used diphosphate （15.1%）. The use of the name bisphosphonate increased in a great deal since 2004, but the use stopped later on. Meanwhile, articles that used two or three names of bishosphonates did not decrease,but increased in a certain extent. Conclusion The use of the names of bisphosphonates still confused in the country. It is still difficult to unify the use of the name of bisphosphonate.