对Bolland等“钙的膳食补充剂与心肌梗死和心血管事件的风险:荟萃分析”一文的解读和思考

Unscramble and Ponder over the article of “Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis”

对"钙的膳食补充剂与心肌梗死和心血管事件的风险:荟萃分析"一文的解读和思考。该回顾性荟萃分析是针对骨质疏松及其风险人群,单纯补充钙剂后其心血管事件的风险变化进行的。结果发现,服用钙剂导致了患心肌梗塞的风险增加,但包括中风发生率或心肌梗塞的复合终点或猝死的其他终点均无显著差异。由于该荟萃分析在研究终点设计、资料和研究的选择、钙补充剂量和依从性等方面存在明显的局限与缺陷,影响了荟萃结果的科学性和真实性。我们强调适量的钙和维生素D补充是防治骨质疏松的基础措施。

Unscramble and ponder over the article ＂ Effect of calcium supplements on risk of myocardial infarction and cardiovascular events： meta-analysis＂. The retrospective meta-analysis assessed whether simple calcium supplement increased the risk of cardiovascular events in people with, or at risk of, osteoporosis. They found that calcium supplements increased the risk of myocardial infarction, but no significant difference in the risk of stroke, or the composite end point of myocardial infarction, stroke, or sudden death. However, the results existed several limitations, such as the end points of objective of the designs, data sources and study selected, dosage of calcium supplement, and compliance of the trails, obviously affecting their scientific and realistic outcomes. We emphasize that adequate supplementation of calcium and vitamin D is the essential strategy for prevention and treatment of osteoporosis.