皮肤肿瘤干细胞研究进展

Advances in skin tumor stem cell research

皮肤肿瘤干细胞与皮肤干细胞有一定的相似性,也有差异性.已经认识一些皮肤肿瘤干细胞表面的标记物,例如CD34、CD44、ABC家族成员、CD133、整合素、P63、CD20、角蛋白15、17和角蛋白19,以及与其相关的Wnt/β-连环蛋白/c-myc通路和Hedgehog/Shh等信号转导通路.探讨皮肤肿瘤干细胞特征性细胞表面标记与生物信号途径的关系,成为深入研究皮肤肿瘤干细胞的热点问题.阐明皮肤肿瘤干细胞表面标记及其信号通路与非肿瘤干细胞之间的异同,将完善皮肤肿瘤干细胞的致病机制,为研究皮肤肿瘤的发生发展、转移和有效根治皮肤肿瘤提供新的思路.

There is not only similarity but also difference between skin tumor stem cells and skin stem cells. Recently, some surface markers and related signal transduction pathway have been identified for skin tumor stem cells, such as CD34, CD44, members of ATP-binding cassette transporter （ABC） family, integrin,P63, CD20, keratin 15, 17 and 19, Wnt/β-catenin/c-myc pathway, Hedgehog/Shh pathways. The relationship between specific cell surface markers for skin tumor stem cells and signaling pathways has become the focus of researches into skin tumor stem cells. To clarify the similarity and difference in surface markers between skin tumor stem cells and skin stem cells will help to understand the pathogenic mechanism of skin tumor stem cells, and to offer new ideas for researches of initiation, progression, metastasis and effective treatment of skin tumors.