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骨桥蛋白在涎腺良、恶性肿瘤中的表达及意义的研究 被引量：2

Osteopontin expression in salivary gland benign and malignant tumor and its significance
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摘要 目的探讨骨桥蛋白(OPN)在涎腺良、恶性肿瘤中的表达及意义。方法采用免疫组化SP法检测OPN在68例涎腺肿瘤(多形性腺瘤20例、腺样囊性癌24例、Warthin瘤24例)和20例瘤旁正常涎腺组织中的表达。结果 OPN在多形性腺瘤和Warthin瘤中均较正常涎腺组织增高(P<0.05);在腺样囊性癌中较正常涎腺组织增高,但两组间比较差异无显著性(P>0.05)。结论 OPN在正常涎腺组织和腺样囊性癌中有弱表达,在多形性腺瘤和Warthin瘤中表达增高。 Objective To examine the expression of OPN in salivary gland benign and malignant tumor and its significance.Methods We examined the expression of OPN in normal salivary gland tissue and three types of salivary gland tumor by immunohistochemistry：pleomorphic adenoma（PA）,Warthin＇s tumor and adenoid cystic carcinoma（ACC）.Results PAs and Warthin＇s tumors desmonstrated higher levels of OPN than normal salivary gland tissues,while ACCs,although showing a trend towards increased OPN,were not significantly different from normal salivary gland tissues.Conclusions The results of this study indicate that OPN weak expression is present in normal salivary gland tissue and ACC,and is increased in PA and Warthin＇s tumor.Further investigation is necessary to clarify its role in salivary gland tumor.
作者 施琳 乌新林 赵利珍 韩菲 萨初然贵
机构地区 内蒙古医学院第一附属医院病理科 内蒙古医学院第一附属医院普外科
出处 《口腔医学》 CAS 2010年第9期517-519,共3页 Stomatology
基金 博士启动基金(NY2006BQ007) 内蒙古自治区自然科学基金(200711020922)
关键词 骨桥蛋白 涎腺肿瘤 免疫组化 osteopontin salivary gland tumor immunohistochemistry
分类号 R739.87 [医药卫生—肿瘤]
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参考文献14

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同被引文献26

  • 1朱耀魁,屈洋,夏明翰,王晓玉,罗新.骨桥蛋白在子宫内膜癌及子宫颈癌组织中的表达[J].中国病理生理杂志,2005,21(12):2414-2417. 被引量：31
  • 2AHMED M, KUNDU G C. Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF - kappaB dependent AP - 1 - mediated ICAM - 1 expression in breast cancer cells[ J]. Mol Cancer, 2010, 9: 101.
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  • 5TAKANO S, TSUBOI K, TOMONO Y, et al. Tissue factor, os- teopontin, alphavbeta3 integrin expression in microvasculature of gliomas associated with vascular endothelial growth factor expres- sion[J]. Br J Cancer, 2000, 82(12) : 1967 -1973.
  • 6SHOJAEI F, SCOT/" N, KANG X, et al. Osteopontin induces growth of metastatic tumors in a preclinieal model of non - small lung cancer[J]. J Exp Clin Cancer Res, 2012, 31 : 26.
  • 7ABU EL MAKAREM M A, ABDEL ALEEM A, ALI A, et al. Di- agnostic significance of plasma osteopontin in hepatitis C virus - re- lated hepatocellular carcinoma[ J ]Ann Hepatol, 2011, 10 (3) : 296 - 305.
  • 8HUA Z, CHEN J, SUN B, et al. Specific expression of osteopon- tin and S100A6 in hepatocellular carcinoma[ J]. Surgery, 2011, 149(6) : 783 -791.
  • 9CHEN R X, XIA Y H, XUE T C, et al. Down - regulation of os- teopontin inhibits metastasis of hepatocellular carcinoma cells via a mechanism involving MMP -2 and uPA[ J]. Oncol Rep, 2011, 25 (3) : 803 - 808.
  • 10BAO L H, SAKAGUCHI H, FUJIMOTO J, et al. Osteopontin in metastatic lesions as a prognostic marker in ovarian cancers [ J ]. J Biomed Sci, 2007, 14(3) : 373 -381.

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口腔医学
2010年 第9期

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