儿童特发性血小板减少性紫癜部分脾动脉栓塞术的临床应用

Clinical application of partial splenic artery embolization in the treatment of children with idiopathic thrombocytopenic purpura

目的:探讨儿童特发性血小板减少性紫癜部分脾动脉栓塞术治疗的临床疗效。方法:选择21例儿童特发性血小板减少性紫癜患者,内科用药无效情况下,采用Seldinger技术用PVA微粒行脾动脉部分栓塞术,并于栓塞术后观察临床疗效。结果:术后1个月血小板平均计数(236.46±107.42)×109/L,术后2年血小板平均计数(201.36±71.36)×109/L。术前及术后血小板计数差异有显著性。有效病例血小板相关抗体下降,以PAIgG下降明显。结论:部分脾动脉栓塞术在儿童特发性血小板减少性紫癜中疗效明显,并发症少,值得临床应用。

Objective：To investigate the clinical efficiency of partial splenic artery embolization （PSE） in the treatment of children with idiopathic thrombocytopenic purpura （ITP）. Methods：21 cases of ITP,which were ineffective with internal medicine,were subject to PSE using Seldinger technique with PVA particles and,subsequently,the efficacy and safety of were evaluated. Results：After one month of the treatment,the average counts of the platelet were （236.46±107.42）×109/L,while,after two years of the treatment,the average counts of the platelet were （201.36±71.36）×109/L. Preoperative and postoperative platelet counts of the treatment were significantly different. The platelet-associated antibodies of the effective cases had decreased,especially,the significant decrease of the PAIgG. Conclusion：PSE is an effective approach for the treatment of children with ITP.