erbB3结合蛋白-ebp1在腺样囊性癌组织中的表达及其临床意义

Expression of ebp1 in adenoid cystic carcinoma and its clinic-pathologic significances

目的研究ebp1在涎腺腺样囊性癌中的表达,并探讨其与病理生物学特征及患者术后生存时间的关系,以期为评价ebp1作为涎腺腺样囊性癌早期诊断和患者预后的可能性提供实验依据。方法采用PV6000二步法免疫组化染色检测有完整随访资料的35例涎腺腺样囊性癌及相应癌旁正常组织中ebp1表达的差异。结果正常涎腺组织中ebp1的阳性表达(97.1%)明显高于涎腺腺样囊性癌组织中(74.3%)的表达(P=0.016)。ebp1蛋白表达强度与肿瘤的组织学类型及分期密切相关(P<0.05),但与患者的年龄、性别和侵袭转移类型无明显相关性(P>0.05)。其中,单纯筛状和筛状管状型ACC中ebp1的表达明显高于坏死型;T1-T2期患者中ebp1表达显著高于T3-T4期患者(P<0.05)。此外,ebp1阳性表达组患者的生存期明显高于ebp1阴性表达组,且具统计学差异(P=0.048)。结论 ebp1的下调可能促进涎腺腺样囊性癌的发生发展,可考虑作为涎腺腺样囊性癌临床评价肿瘤生物学行为及评估预后的指标。

Objective To investigate the expression of ebp1 in adenoid cystic carcinoma and its clinic-pathologic significance. Methods Immunohistochemistry（PV6000 method） was used to detect ebp1 expression in paraffin-embedded adenoid cystic carcinoma tissues of 35 cases and matched para-cancerous normal tissues.In this study all cases were successfully followed up. Results The positive expression rate of ebp1 in adenoid cystic carcinoma tissues was 74.3%.ebp1 expression was significantly correlated to pathological pattern and clinical stage（P0.05）,but not correlated to gender and age（P0.05）.In addition,the 5-year survival rate of the patients with ebp1 expression was higher than those with negative expression（P0.05）. Conclusions ebp1 plays an important role in the generation and evolution of adenoid cystic carcinoma,and can be used as an useful indicator for clinical assessment of tumor biological behavior and prognosis in patients with adenoid cystic carcinoma.