Rho亚家族在肿瘤侵袭中的作用研究进展

Advances in the role of Rho sub-family in tumor invasion

Rho家族是Ras超家族中小分子量G蛋白的成员之一。Rho亚家族成员RhoA、RhoB、RhoC在多种恶性肿瘤中异常表达,参与肿瘤的发生和发展,它们通过调节肌动蛋白微丝骨架的聚合,影响细胞的极性和形态,从而在细胞运动、细胞-细胞间及细胞-基质间黏附和细胞外基质重建方面参与肿瘤细胞的侵袭。深入研究Rho亚家族将有助于加深对肿瘤侵袭的了解,为预防肿瘤转移提供特异性、多靶位的治疗方法。

Rho family is a member of small G protein in Ras superfamily.Rho subfamily members RhoA,RhoB,and RhoC are abnormally expressed in a variety of malignant tumors,and involved in the occurrence and development of tumors.Through regulating the actin cytoskeleton polymerization,cell polarity and morphology,they affect cell movement,cell-cell and cell-matrix adhesion and reconstruction of extracellular matrix,and are involved in the process of the invasion of malignant cells.Further study on Rho subfamily may deepen our understanding on tumor invasion,which provide specific and multi-target therapy to the prevention of tumor metastasis.