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Vascular and Morphogenetic Abnormalities Associated with Exposure of Cigarette Smoke Condensate during Chicken and Murine Embryogenesis 被引量:2

Vascular and Morphogenetic Abnormalities Associated with Exposure of Cigarette Smoke Condensate during Chicken and Murine Embryogenesis
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摘要 Objective Embryonic movements (EM) and angiogenesis pathways are evolutionarily conserved mechanisms which are essential for proper embryonic development. Deviations in these processes by exposure to cigarette smoke condensate (CSC) may cause vascular and morphogenetic disorders. Methods Using chicken and mouse embryos, we have demonstrated the in vivo effects of CSC on EM, vascular development, and organogenesis. Results Examination of the CSC exposed chicken embryos revealed a significant reduction in EM, stunted growth, deviated pattern of blood vessels, hemorrhages, and localized necrosis. Likewise, mouse embryos that were exposed to CSC at E8.5 and E9.5 died between E11.5 and E12.5, respectively. These mouse embryos showed defects in morphogenesis and remodeling of the embryonic vasculature, while littermate controls showed normal development. Conclusion Cigarette smoking during pregnancy is fatal for growing embryos. CSC may induce the remodeling of embryonic vasculature, leading to various pathologies. Objective Embryonic movements (EM) and angiogenesis pathways are evolutionarily conserved mechanisms which are essential for proper embryonic development. Deviations in these processes by exposure to cigarette smoke condensate (CSC) may cause vascular and morphogenetic disorders. Methods Using chicken and mouse embryos, we have demonstrated the in vivo effects of CSC on EM, vascular development, and organogenesis. Results Examination of the CSC exposed chicken embryos revealed a significant reduction in EM, stunted growth, deviated pattern of blood vessels, hemorrhages, and localized necrosis. Likewise, mouse embryos that were exposed to CSC at E8.5 and E9.5 died between E11.5 and E12.5, respectively. These mouse embryos showed defects in morphogenesis and remodeling of the embryonic vasculature, while littermate controls showed normal development. Conclusion Cigarette smoking during pregnancy is fatal for growing embryos. CSC may induce the remodeling of embryonic vasculature, leading to various pathologies.
出处 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2010年第4期305-311,共7页 生物医学与环境科学(英文版)
基金 supported by the grant from Post Doctor Program, Chonbuk National University (2008)
关键词 ANGIOGENESIS Embryonic movements Cigarette smoke condensate Vascular remodeling Angiogenesis Embryonic movements Cigarette smoke condensate Vascular remodeling
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  • 1Szarvas T, Jager T, Droste F, et al. (2008). Serum Levels of Angiogenic Factors and their Prognostic Relevance in Bladder Cancer. Pathol Oncol Res 15(2), 193-201.
  • 2McDonald P C, Fielding A B, Dedhar S (2008). Integrin-linked kinase - essential roles in physiology and cancer biology. J Cell Sci 121, 3121-3132.
  • 3Folkman J (1995). Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1, 27-31.
  • 4Folkman J (2001). A new family of mediators of tumor angiogenesis. Cancer Invest 19, 754-755.
  • 5Kramer U, Esser C (2006). Cigarette smoking, metabolic gene polymorphism, and psoriasis. Jlnvest Dermatol 126, 693-694.
  • 6Cekic O (1998). Effect of cigarette smoking on copper, lead, and cadmium accumulation in human lens. Br J Ophthalmo182, 186-188.
  • 7Grogan S, Fry G, Gough B, et al. (2008). Smoking to stay thin or giving up to save face? Young men and women talk about appearance concerns and smoking. Br J Health Psychol 14(1), 175-186.
  • 8Sun W, Hansen A, Zhang L, et al. (2008). Neonatal nicotine exposure impairs development of auditory temporal processing. Hear Res 245(1-2), 58-64.
  • 9Petersen P E (2008). Oral cancer prevention and control - The approach of the World Health Organization. Oral Onco145(4-5), 454-460.
  • 10Vellappally S, Jacob V, Smejkalova J, et al. (2008). Tobacco habits and oral health status in selected Indian population. Cent Eur J Public Health 16, 77-84.

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  • 1Puett R C, Hart J E, Yanosky J D, et al. Particulate matter air pollutionexposure, distance to road, and incident lung cancer in the nurses" health study cohort[J]. Environmental Health Perspectives, 2014, doi: 10.1289/ehp. 1307490.
  • 2Bakand S, Hayes A, Dechsakuhhorn F. Nanoparticles: A review of particle toxicology following inhalation exposure[J]. Inhalation Toxicology, 2012, 24(2): 125-135.
  • 3Meng X, Ma Y, Chen R, et al. Size-fractionated particle number concentrations and daily mortality in a Chinese city[J]. Environmental Health Perspectives, 2013, 121(10): 1174-1178.
  • 4Hamra G B, Guha N, Cohen A, et al. Outdoor particulate matter exposure and lung cancer: A systematic review and meta-analysis[J]. Environmental Health Perspectives, 2014.
  • 5Mahalingaiah S, Hart J E, Laden F, et al. Air pollution and risk of uterine leiomyomata[J]. Epidemiology, 2014, 25(5): 682-688.
  • 6Nursan C, Muge A T, Cemile D, et al. Parent's knowledge and perceptions of the health effects of environmental hazards in Sakarya, Turkey[J]. Journal of the Pakistan Medical Association, 2014, 64(1): 38-41.
  • 7Kampa M, Castanas E. Human health effects of air pollution[J]. Environmental Pollution, 2008, 151(2): 362-368.
  • 8Chen H, Goldberg M S, Villeneuve P J. A systematic review of the relation between long-term exposure to ambient air pollution and chronic diseases[J]. Reviews on Environmental Health, 2008, 23(4): 243-297.
  • 9Liu L, Breitner S, Schneider A, et al. Size-fractioned particulate air pollution and cardiovascular emergency room visits in Beijing, China [J]. Environmental Research, 2013, 121: 52-63.
  • 10Guo Y, Li S, Tian Z, et al. The burden of air pollution on years of life lost in Beijing, China, 2004-08: Retrospective regression analysis of daily deaths[J]. British MediCal Journal, 2013, 347: 17139.

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