CD44蛋白在非小细胞肺癌中的表达及其临床意义

THE EXPRESSION AND CLINICAL SIGNIFICANCE OF CD44 IN NON-SMALL CELL LUNG CANCER

目的:研究CD44在非小细胞肺癌中的表达及其临床意义,并探讨其表达的相关性。方法:应用S-P免疫组化方法,检测75例非小细胞肺癌组织和25例正常肺组织中CD44蛋白表达水平。结果:CD44蛋白在肺癌组织中阳性表达49例,阳性率为65.33(;正常组织中阳性表达5例,阳性率为20.00(,两者比较差异有显著性(P(0.01)。CD44与肿瘤的临床分期、淋巴结转移和患者的生存期有明显相关性(P(0.05)。结论:CD44在非小细胞肺癌(NSCLC)组织中均异常表达,与NSCLC的发生发展密切相关,可作为NSCLC诊断的标志物。CD44在NSCLC的发生发展中起协同作用,联合检测CD44表达对于临床选择高危复发病例,给予积极治疗,提高预后水平具有重要意义,并可作为建立NSCLC预后模型的重要指标。

Objective：To study the expression,correlation and clinical significance ofCD44 in non-small lung cancer（NSCLC）.Methods：Immunohistochemical method was employed to examine 75 samples of NSCLC and 25 samples of normal lung tissue adjacent to the cancer focus.Results： The expression of CD44 protein in NSCLC was 65.33%,much higher than normal tissue 20%（P〈0.05）.There was correlation between CD44 protein expression and TNM staging,five-year-survive differentiation,and lymphatic metastasis;and no correlation between expression of CD44 protein age and sex.Conclusion： The expression of CD44 in cancer focus was much higher than in normal tissue,and correlated to differentiation of NSCLC,in squamous significant higher than in adenocarcinoma,it could be helpful for the diagnosis,differentiation,therapeutic selection and prognosis.