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T-bet对支气管哮喘小鼠Th17细胞增殖和致炎机能的影响 被引量：3

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摘要 T—bet是Th1细胞分化的重要因子，Th17细胞是不同于Th1的细胞亚群，转录因子孤独受体（RORγt）控制其分化、诱导编码白细胞介素（IL）-17的表达。本研究为探讨T—bet的表达是否影响Th17细胞的增值和IL-17的分泌，采用小干扰RNA（siRNA）片段瞬时转染小鼠脾CD4^＋T细胞后，检测沉默效率，选择最佳siRNA片段。测定对照组、未转染哮喘组和转染最佳siRNA片段哮喘组的小鼠脾CD4^＋T细胞中T-bet表达、
作者 杨沫毅 李金秀 刘绍坤 刘毅 王谷宜 朱岳 Binaya Wasti 向旭东
机构地区 中南大学湘雅二医院呼吸内科
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2010年第9期704-705,共2页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 湖南省财政厅教育经费专项基金（湘财教指[2008]56号） 湖南省“十一五”重点学科建设经费（湘财教指[2008]69号）
关键词 哮喘小鼠 T-BET 细胞增殖 CD4^+T细胞 Th17细胞 支气管 RNA片段 机能
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献9

  • 1沈华浩,王苹莉.支气管哮喘小鼠模型应用评价[J].中华结核和呼吸杂志,2005,28(4):284-286. 被引量：65
  • 2North ML,Khanna N,Marsden PA,et al.Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma.Am J Physiol Lung Cell Mol Physiol,2009,296:L911-L920.
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  • 5黄玲,向旭东,王文军,邓军卫,陈平.罗格列酮对支气管哮喘急性发作期患者T淋巴细胞转录因子T-bet/GATA-3表达的调控[J].中华结核和呼吸杂志,2007,30(2):116-120. 被引量：10
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二级参考文献20

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共引文献73

同被引文献58

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中华结核和呼吸杂志
2010年 第9期

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