白细胞介素-11结缔组织生长因子对乳腺癌骨转移的诊断价值分析

Diagnostic Value of IL-11 and CTGF Detection for Bone Metastasis of Breast Cancer

目的:研究白细胞介素-11(IL-11)和结缔组织生长因子(CTGF)对乳腺癌的诊断价值,探索新的乳腺癌早期诊断的标志物。方法:对180例经病理证实的乳腺癌及45例其他癌骨转移患者的外周血标本进行研究,以20例健康女性外周血标本作对照,应用酶联免疫法定量检测血中IL-11与CTGF的含量。结果:IL-11在乳腺癌骨转移组、未发生骨转移组与正常对照组之间差异均有统计学意义(P<0.05),在乳腺癌骨转移组明显升高,而CTGF在各组间比较差异无统计学意义(P>0.05)。两两进行比较发现IL-11在乳腺癌骨转移组明显升高(P<0.05),但在乳腺癌未发生骨转移组与健康对照组比较差异无统计学意义(P>0.05)。IL-11在乳腺癌骨转移中的水平与其他肿瘤骨转移的表达水平相比差异有统计学意义(P<0.05)。IL-11与乳腺癌骨转移患者的年龄、骨痛程度及骨转移程度密切相关(P<0.05)。结论:IL-11的定量检测有助于乳腺癌骨转移的诊断,有望成为乳腺癌骨转移的血清标志物。

Objective： To investigate the value of interleukin-11 （IL-11） and connective tissue growth factor （CTGF） in the diagnosis of bone metastasis of human breast cancer and to explore new markers for early diagnosis of bone metastasis of human breast cancer. Methods： The serum levels of IL-11 and CTGF in 180 cases of breast cancer, 45 cases of bone metastasis of other types of cancer, and that of 20 healthy controls were determined by ELISA assay. Results： IL-11 level was significantly higher in breast cancer patients with bone metastasis than in healthy controls and patients with no bone metastasis （P〈0.05）. CTGF showed no statistical significance （P〉0.05） among these groups. Compared to the healthy control group, CTGF level was higher in the breast cancer bone metastasis group （P〈0.05）, but showed no significant difference in the breast cancer with no bone metastasis group （P〉0.05）. IL-11 level was higher in the breast cancer patients with bone metastasis （P〈0.05） and showed no significant difference in the breast cancer patients with no bone metastasis （P〉 0.05）, when compared with healthy controls. In patients with bone metastasis of breast cancer, IL-11 level was correlated with patient age, the degree of bone pain and level of bone metastasis （P〈0.05）. Conclusion： The quantitative determination of IL-11 is helpful for the diagnosis of bone metastasis of breast cancer and could be used as a new serum marker.