组织工程韧带支架材料在体内的转归

In vivo turnover of tissue engineered ligament scaffold materials

背景:组织工程韧带由于具有自我更新和改建能力,生物力学性能优良,从而克服了现有人造韧带的不足,有望成为理想的韧带替代物,且已成为目前韧带修复重建外科领域关注的热点。目的:通过分析和总结1998年以来采用复合培养支架移植修复损伤韧带的研究,以寻求适合组织工程韧带的新型支架材料及适用标准。方法:分别以"韧带、组织工程、支架材料、细胞外基质","Ligament、Tissue Engineering,、Scaffold material、ECM"为检索词,应用计算机检索Pubmed数据库及重庆维普期刊全文数据库1998-01/2009-12有关文章。纳入有关组织工程韧带的文献。排除与研究目的无关和内容重复者。保留31篇文献做进一步分析。结果与结论:韧带和肌腱损伤的治疗已研究较多,但对其修复重建以至完全恢复到受伤前的功能水平,迄今尚未实现。组织工程韧带的出现可能给韧带和肌腱损伤提供理想的治疗途径。组织工程支架材料研究结果报道越来越多,然而均各有利弊,绝大多数还处于研究阶段。目前仍在寻找一种完全合适的支架材料来治疗韧带损伤。

BACKGROUND：Due to the abilities of self-update and reconstruction capacities,as well as excellent performance of biomechanics,tissue-engineered ligament overcomes the deficiency of existing man-made ligaments,and is expected to become ideal substitute.It has already become the focus of ligament reconstruction surgery field.OBJECTIVE：To analyze and summarize the studies regarding the injured ligament repaired by cultured composite scaffolds since 1998,and to find suitable new scaffold materials for tissue engineered ligament and their applicable standards.METHODS：Using ＂ligament,tissue engineering,scaffold materials,extracellular matrix＂ in Chinese and in English as the key words,a computer retrieval was performed in VIP Periodical Full-Text Database and PubMed Database for articles on tissue-engineered ligament from January 1998 to December 2009.Literatures of irrelevant objective and repetitive content were excluded.Thirty-two literatures were involved in further analysis. RESULTS AND CONCLUSION：There are many studies about the treatments of ligaments and tendons injury,but it is very difficult to repair,reconstruct or completely recover pre-injury function.Tissue engineered ligament provides an ideal treatment for injured ligaments and tendons.There are an increasing number of researches reported tissue engineered scaffolds materials,however,each of them has benefits and shortcomings,and a majority of reports are in studies yet.Currently an ideal scaffold for tissue engineered ligament is still needed to treat injured ligaments and tendons.